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Shaping the Future

Hermes Garban, M.D., Ph.D.

Contact Information:

Work Phone Number:

(310) 222-8011

Mailing Address:

Main Office
1124 West Carson Street
Los Angeles, CA 90052
UNITED STATES

Work Email Address:

hgarban@mednet.ucla.edu

Website:

  

Home Page:

     Web Profile


Associate Professor, Surgical Oncology

Member, CTSI


A Short Biography:

Dr. Hermes Garban�s research focuses on three major areas: molecular tumor immunobiology, regulation of gene expression and nitric oxide biology and signaling. Tumor immune-tolerance is one of multiple mechanisms utilized by cancer cells in order to evade the immune system. Garban�s laboratory studies the molecular mechanisms involved in the tumor-dependent modulation of immune-tolerance and tumor resistance to programmed cell death or apoptosis. Their central hypothesis is that cancer cells are acquiring a new profile of gene expression by the activation of genetic and/or epigenetic signals that are directing the survival of cancer cells even in a perfectly normal immunocompetent environment. Thus, determining the mechanisms of control of these ectopically expressed genes (i.e., FOXP3, ROBO4, COX2, YY1, TRAF6, Survivin, etc.) and their role in tumor-derived immune-tolerance and resistance to apoptosis will provide new insight in the mechanisms of tumor immune evasion, define better-targeted immunotherapy strategies and improve the effectiveness of conventional therapies against cancer. In addition, Garban�s lab is interested in studying the role of Nitric Oxide (NO) and other reactive oxygen species (ROS) in the regulation of gene expression in the above-mentioned paradigm.

Publications:

Zhu Weidong, Olson Samuel Y, Garbán Hermes   Transcription regulator Yin-yang 1: from silence to cancer Critical reviews in oncogenesis, 2011; 16(3-4): 227-38.
Vo Dan D, Prins Robert M, Begley Jonathan L, Donahue Timothy R, Morris Lilah F, Bruhn Kevin W, de la Rocha Pilar, Yang Meng-Yin, Mok Stephen, Garban Hermes J, Craft Noah, Economou James S, Marincola Francesco M, Wang Ena, Ribas Antoni   Enhanced antitumor activity induced by adoptive T-cell transfer and adjunctive use of the histone deacetylase inhibitor LAQ824 Cancer research, 2009; 69(22): 8693-9.
Begley Jonathan, Vo Dan D, Morris Lilah F, Bruhn Kevin W, Prins Robert M, Mok Stephen, Koya Richard C, Garban Hermes J, Comin-Anduix Begonya, Craft Noah, Ribas Antoni   Immunosensitization with a Bcl-2 small molecule inhibitor Cancer immunology, immunotherapy : CII, 2009; 58(5): 699-708.
Olson Samuel Y, Garbán Hermes J   Regulation of apoptosis-related genes by nitric oxide in cancer Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society, 2008; 19(2): 170-6.
Huerta-Yepez Sara, Vega Mario, Garban Hermes, Bonavida Benjamin   Involvement of the TNF-alpha autocrine-paracrine loop, via NF-kappaB and YY1, in the regulation of tumor cell resistance to Fas-induced apoptosis Clinical immunology (Orlando, Fla.), 2006; 120(3): 297-309.
Ribas Antoni, Vo Dan D, Weeks David L, Comin-Anduix Begoña, Schumacher Lana Y, Garban Hermes J, McLean Colin, Yang Jinquan, Dissette Vivian B, Peraza Pedro, Owens Sharla K, McBride William H, Glaspy John A, Economou James S   Broad antitumor protection by dendritic cells administered to CD8alpha knock out mice Cancer immunology, immunotherapy : CII, 2006; 55(6): 663-71.
Bonavida Benjamin, Khineche Soraya, Huerta-Yepez Sara, Garbán Hermes   Therapeutic potential of nitric oxide in cancer Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy, 2006; 9(3): 157-73.
Schumacher Lana Y, Vo Dan D, Garban Hermes J, Comin-Anduix Begoña, Owens Sharla K, Dissette Vivian B, Glaspy John A, McBride William H, Bonavida Benjamin, Economou James S, Ribas Antoni   Immunosensitization of tumor cells to dendritic cell-activated immune responses with the proteasome inhibitor bortezomib (PS-341, Velcade) Journal of immunology (Baltimore, Md. : 1950), 2006; 176(8): 4757-65.
Weinberg Olga K, Marquez-Garban Diana C, Fishbein Michael C, Goodglick Lee, Garban Hermes J, Dubinett Steven M, Pietras Richard J   Aromatase inhibitors in human lung cancer therapy Cancer research, 2005; 65(24): 11287-91.
Vega Mario I, Huerta-Yepez Sara, Jazirehi Ali R, Garban Hermes, Bonavida Benjamin   Rituximab (chimeric anti-CD20) sensitizes B-NHL cell lines to Fas-induced apoptosis Oncogene, 2005; 24(55): 8114-27.
Hongo Fumiya, Garban Hermes, Huerta-Yepez Sara, Vega Mario, Jazirehi Ali R, Mizutani Yoichi, Miki Tsuneharu, Bonavida Benjamin   Inhibition of the transcription factor Yin Yang 1 activity by S-nitrosation Biochemical and biophysical research communications, 2005; 336(2): 692-701.
Seligson David, Horvath Steve, Huerta-Yepez Sara, Hanna Stephanie, Garban Hermes, Roberts Alice, Shi Tao, Liu Xueli, Chia David, Goodglick Lee, Bonavida Benjamin   Expression of transcription factor Yin Yang 1 in prostate cancer International journal of oncology, 2005; 27(1): 131-41.
Garbán Hermes J, Márquez-Garbán Diana C, Pietras Richard J, Ignarro Louis J   Rapid nitric oxide-mediated S-nitrosylation of estrogen receptor: regulation of estrogen-dependent gene transcription Proceedings of the National Academy of Sciences of the United States of America, 2005; 102(7): 2632-6.
Huerta-Yepez Sara, Vega Mario, Jazirehi Ali, Garban Hermes, Hongo Fumiya, Cheng Genhong, Bonavida Benjamin   Nitric oxide sensitizes prostate carcinoma cell lines to TRAIL-mediated apoptosis via inactivation of NF-kappa B and inhibition of Bcl-xl expression Oncogene, 2004; 23(29): 4993-5003.
Garbán Hermes J, Buga Georgette M, Ignarro Louis J   Estrogen receptor-mediated vascular responsiveness to nebivolol: a novel endothelium-related mechanism of therapeutic vasorelaxation Journal of cardiovascular pharmacology, 2004; 43(5): 638-44.
Vega Mario I, Huerta-Yepaz Sara, Garban Hermes, Jazirehi Ali, Emmanouilides Christos, Bonavida Benjamin   Rituximab inhibits p38 MAPK activity in 2F7 B NHL and decreases IL-10 transcription: pivotal role of p38 MAPK in drug resistance Oncogene, 2004; 23(20): 3530-40.
Magee Thomas R, Ferrini Monica, Garban Hermes J, Vernet Dolores, Mitani Kohnosuke, Rajfer Jacob, Gonzalez-Cadavid Nestor F   Gene therapy of erectile dysfunction in the rat with penile neuronal nitric oxide synthase Biology of reproduction, 2002; 67(3): 1033-41.
Magee Thomas R, Ferrini Monica, Garban Hermes J, Vernet Dolores, Mitani Kohnosuke, Rajfer Jacob, Gonzalez-Cadavid Nestor F   Gene therapy of erectile dysfunction in the rat with penile neuronal nitric oxide synthase Biology of reproduction, 2002; 67(1): 20-8.
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