Jeffrey Zink, Ph.D.

A Short Biography:

Professor Zink received his B.S degree in Chemistry from the University of Wisconsin, and his PhD degree from the University of Illinois in 1970. He joined the faculty at UCLA in 1970.

Work Titles
California NanoSystems Institute Member, NanoElectronics, Photonics, Architectonics Member, NanoMechanical and Nanofluidic Systems Member, California NanoSystems Institute
UCLA Professor, Chemistry and Biochemistry Professor, Inorganic Chemistry Professor, Physical Chemistry Researcher, Inorganic Researcher, Nanoscience and Materials Researcher, Physical
Ph.D., University of Illinois, 1970
Honors and Awards:
National Science Council of Taiwan, Visiting Lecturer
University of Amsterdam, Invited Visiting Professor
SUNY Buffalo, Foster Chemistry Colloquium Lecturer
John Simon Guggenheim Fellow
Dow-Hansen Distinguished Teaching Award
University of Paris, Invited Visiting Professor
US Department of Energy Materials Sciences, Outstanding Scientific Accomplishment in Metals and Ceramic Sciences
University of Oklahoma, J. Clarence Karcher Lecturer

Contact Information:

Email Address:

Work Email Address:


Lab Number:

1 (310) 825-8651

Work Phone Number:

1 (310) 825-1001

Laboratory Address:

Mol Sci Bldg 2230
Mail Code: 156905
Los Angeles, CA 90095

Work Address:

Mol Sci Bldg 2505A
Mail Code: 156905
Los Angeles, CA 90095

Detailed Biography:

Professor Zink has been a Faculty member in the Department of Chemistry and Biochemistry since 1970. He received his B.S. degree in Chemistry at the University of Wisconsin. He came to UCLA after receiving his PhD degree from the University of Illinois under the direction of Russell S. Drago. He is a Distinguished Professor of Chemistry and a member of the California Nanosystems Institute. He has been an invited guest professor at the University of Paris VI and at the University of Amsterdam, and serves as an ACS tour speaker. He is an authority on triboluminescence, photochemistry and photophysics of metal-containing molecules, and on nanomachines, and has published almost 400 articles. His current research is focused on fundamental spectroscopic investigation of large metal-containing molecules and on design, operation and biological applications of functional nanomaterials including nanomachines such as valves and impellers.


Saji George, Sijie Lin, Zhaoxia Ji, Courtney R. Thomas, LinJiang L, Mathew Mecklenburg, Huan Meng, Xiang Wang, Haiyuan Zhang, Tian Xia, J. Nathan Hohman, Shuo Lin, Jeffrey I. Zink, Paul S. Weiss, and André E. Nel   Surface Defects on Plate-Shaped Silver Nanoparticles Contribute to Its Hazard Potential in a Fish Gill Cell Line and Zebrafish Embryos ACS Nano, 2012; 6(5): 3745-3759.
Zhang Haiyuan, Ji Zhaoxia, Xia Tian, Meng Huan, Low-Kam Cecile, Liu Rong, Pokhrel Suman, Lin Sijie, Wang Xiang, Liao Yu-Pei, Wang Meiying, Li Linjiang, Rallo Robert, Damoiseaux Robert, Telesca Donatello, Mädler Lutz, Cohen Yoram, Zink Jeffrey I, Nel Andre E   Use of Metal Oxide Nanoparticle Band Gap To Develop a Predictive Paradigm for Oxidative Stress and Acute Pulmonary Inflammation ACS nano, 2012; 56(5): .
Xia T, Zhao Y, Sager T, George S, Pokhrel S, Li N, Schoenfeld D, Meng H, Lin S, Wang X, Wang M, Ji Z, Zink JI, Mädler L, Castranova V, Lin S, Nel AE   Decreased Dissolution of ZnO by Iron Doping Yields Nanoparticles with Reduced Toxicity in the Rodent Lung and Zebrafish Embryos ACS Nano, 2011; 5(2): 1223-35.
Zhang H, Xia T, Meng H, Xue M, George S, Ji Z, Wang X, Liu R, Wang M, France B, Rallo R, Damoiseaux R, Cohen Y, Bradley KA, Zink JI, Nel AE   Differential Expression of Syndecan-1 Mediates Cationic Nanoparticle Toxicity in Undifferentiated versus Differentiated Normal Human Bronchial Epithelial Cells ACS Nano, 2011; 5(4): 2756-69.
George S, Xia T, Rallo R, Zhao Y, Ji Z, Lin S, Wang X, Zhang H, France B, Schoenfeld D, Damoiseaux R, Liu R, Lin S, Bradley KA, Cohen Y, Nel AE   Use of a High-Throughput Screening Approach Coupled with In Vivo Zebrafish Embryo Screening To Develop Hazard Ranking for Engineered Nanomaterials ACS Nano, 2011; 5(3): 1805-17.
Thomas, C. R., Ferris, D. P., Lee, J. H., Choi, E., Cho, M. H., Kim, E. S., Stoddart, J. F., Shin, J.-S., Cheon, J. and Zink, J. I.   Noninvasive Remote-Controlled Release of Drug Molecules in Vitro Using Magnetic Actuation of Mechanized Nanoparticles Journal of the American Chemical Society, 2010; 132(31): 10623-10625.
Huan Meng, Min Xue, Tian Xia, Yan-Li Zhao, Fuyuhiko Tamanoi, J. Fraser Stoddart, Jeffrey I. Zink and Andre E. Nel   Autonomous in Vitro Anticancer Drug Release from Mesoporous Silica Nanoparticles by pH-Sensitive Nanovalves J. Am. Chem. Soc, 2010; 132(36): 12690-7.
Jie Lu, Monty Liong, Zongxi Li, Jeffrey I. Zink, Fuyuhiko Tamanoi   Biocompatibility, Biodistribution, and Drug-Delivery Efficiency of Mesoporous Silica Nanoparticles for Cancer Therapy in Animals Small, 2010; 6(16): 1794-1805.
Ji Z, Jin X, George S, Xia T, Meng H, Wang X, Suarez E, Zhang H, Hoek EM, Godwin H, Nel AE, Zink JI   Dispersion and Stability Optimization of TiO(2) Nanoparticles in Cell Culture Media Environ Sci Technol, 2010; 44(19): 7309-14.
Huan Meng, Monty Liong, Tian Xia, Zongxi Li, Zhaoxia Ji, Jeffrey I. Zink and Andre E. Nel   Engineered Design of Mesoporous Silica Nanoparticles to Deliver Doxorubicin and P-Glycoprotein siRNA to Overcome Drug Resistance in a Cancer Cell Line ACS Nano, 2010; 4(8): 4539-4550.
Stephenson RM, Wang X, Coskun A, Stoddart JF, Zink JI   Excited state distortions in a charge transfer state of a donor-acceptor [2]rotaxane Phys Chem Chem Phys, 2010; 12(42): 14135-43.
Kabehie S, Xue M, Stieg AZ, Liong M, Wang KL, Zink JI   Heteroleptic copper switches J Am Chem Soc, 2010; 132(45): 15987-96.
Lockard JV, Kabehie S, Zink JI, Smolentsev G, Soldatov A, Chen LX   Influence of ligand substitution on excited state structural dynamics in Cu(I) bisphenanthroline complexes J Phys Chem B, 2010; 114(45): 14521-7.
Evans WJ, Fang M, Bates JE, Furche F, Ziller JW, Kiesz MD, Zink JI   Isolation of a radical dianion of nitrogen oxide (NO)(2-) Nat Chem, 2010; 2(8): 644-7.
Ambrogio MW, Pecorelli TA, Patel K, Khashab NM, Trabolsi A, Khatib HA, Botros YY, Zink JI, Stoddart JF   Snap-top nanocarriers Org Lett, 2010; 12(16): 3304-7.
Hoekstra RM, Telo JP, Wu Q, Stephenson RM, Nelsen SF, Zink JI   Solvent Effects on the Coexistence of Localized and Delocalized 4,4'-Dinitrotolane Radical Anion by Resonance Raman Spectroscopy J Am Chem Soc, 2010; 132(26): 8825-7.
Zhao YL, Li Z, Kabehie S, Botros YY, Stoddart JF, Zink JI   pH-operated nanopistons on the surfaces of mesoporous silica nanoparticles J Am Chem Soc, 2010; 132(37): 13016-25.
Hom, C., Lu, J., Liong, M., Luo, H., Li, Z., Zink, J.I., Tamanoi, F.   Mesoporous Silica Nanoparticles Facilitate Delivery of siRNA to Shutdown Signaling Pathways in Mammalian Cells Small, 2010; 6(11): 1185-90.
Du L, Liao S, Khatib HA, Stoddart JF, Zink JI   Controlled-access hollow mechanized silica nanocontainers J Am Chem Soc, 2009; 131(42): 15136-42.
Angelos S, Yang YW, Khashab NM, Stoddart JF, Zink JI   Dual-controlled nanoparticles exhibiting AND logic J Am Chem Soc, 2009; 131(32): 11344-6.
Evans WJ, Fang M, Zucchi G, Furche F, Ziller JW, Hoekstra RM, Zink JI   Isolation of dysprosium and yttrium complexes of a three-electron reduction product in the activation of dinitrogen, the (N2)3- radical J Am Chem Soc, 2009; 131(31): 11195-202.
Ferris DP, Zhao YL, Khashab NM, Khatib HA, Stoddart JF, Zink JI   Light-operated mechanized nanoparticles J Am Chem Soc, 2009; 131(5): 1686-8.
Cotí KK, Belowich ME, Liong M, Ambrogio MW, Lau YA, Khatib HA, Zink JI, Khashab NM, Stoddart JF   Mechanised nanoparticles for drug delivery Nanoscale, 2009; 1(1): 16-39.
Klichko Y, Liong M, Choi E, Angelos S, Nel AE, Stoddart JF, Tamanoi F, Zink JI   Mesostructured Silica for Optical Functionality, Nanomachines, and Drug Delivery J Am Ceram Soc, 2009; 92(s1): s2-s10.
Philip X. Rutkowski and Jeffrey I. Zink   Photofragmentation Pathways and Photodeposition of Nanoparticles from a Gas Phase Copper-Containing Precursor Inorg. Chem, 2009; 48(4): 1655–1660.
Xia T, Kovochich M, Liong M, Meng H, Kabehie S, George S, Zink JI, Nel AE   Polyethyleneimine coating enhances the cellular uptake of mesoporous silica nanoparticles and allows safe delivery of siRNA and DNA constructs ACS Nano, 2009; 3(10): 3273-86.
Hoekstra RM, Dibrell MM, Weaver MN, Nelsen SF, Zink JI   Three-chromophore excited-state mixed valence J Phys Chem A, 2009; 113(2): 456-63.
Angelos S, Khashab NM, Yang YW, Trabolsi A, Khatib HA, Stoddart JF, Zink JI   pH clock-operated mechanized nanoparticles J Am Chem Soc, 2009; 131(36): 12912-4.
Khashab NM, Belowich ME, Trabolsi A, Friedman DC, Valente C, Lau Y, Khatib HA, Zink JI, Stoddart JF   pH-responsive mechanised nanoparticles gated by semirotaxanes Chem Commun (Camb), 2009; 36: 5371-3.
Valverde-Aguilar, G. Wang, X. H. Plummer, E. Lockard, J. V. Zink, J. I. Luo, Y. Weaver, M. N. Nelsen, S. F.   Tuning aryl, hydrazine radical cation electronic interactions using substitutent effects Journal of Physical Chemistry A, 2008; 112(32): 7332-7341.
Xia, T. Kovochich, M. Liong, M. Zink, J. I. Nel, A. E.   Cationic polystyrene nanosphere toxicity depends on cell-specific endocytic and mitochondrial injury pathways Acs Nano, 2008; 2(1): 85-96.
Xia, T. Kovochich, M. Liong, M. Madler, L. Gilbert, B. Shi, H. B. Yeh, J. I. Zink, J. I. Nel, A. E.   Comparison of the Mechanism of Toxicity of Zinc Oxide and Cerium Oxide Nanoparticles Based on Dissolution and Oxidative Stress Properties Acs Nano, 2008; 2(10): 2121-2134.
Huang, M. H. Soyez, H. M. Dunn, B. S. Zink, J. I. Sellinger, A. Brinker, C. J.   In situ fluorescence probing of the chemical and structural changes during formation of hexagonal phase cetyltrimethylammonium bromide and lamellar phase CTAB/Poly(dodecylmethacrylate) sol-gel silica thin films Journal of Sol-Gel Science and Technology, 2008; 47(3): 300-310.
Johansson, E. Choi, E. Angelos, S. Liong, M. Zink, J. I.   Light-activated functional mesostructured silica Journal of Sol-Gel Science and Technology, 2008; 46(3): 313-322.
Lu, J., Choi, E., Tamanoi, F., Zink, J. I.   Light-activated nanoimpeller-controlled drug release in cancer cells Small, 2008; 4(4): 421-426.
J. Lu, M. Liong, S. Sherman, T. Xia, M. Kovochich, A. E. Nel, J. I. Zink, and F. Tamanoi   Mesoporous Silica Nanoparticles for Cancer Therapy: Energy-Dependent Cellular Uptake and Delivery of Paclitaxel to Cancer Cells Nanobiotechnol, 2008; 3: 89-95.
Liong, M. Lu, J. Kovochich, M. Xia, T. Ruehm, S. G. Nel, A. E. Tamanoi, F. Zink, J. I.   Multifunctional inorganic nanoparticles for imaging, targeting, and drug delivery Acs Nano, 2008; 2(5): 889-896.
Sarah Angelos, Ying-Wei Yang, Dr., Kaushik Patel, J. Fraser Stoddart, Prof. , Jeffrey I. Zink, Prof.   Nanovalves for Drug Delivery Angewandte Chemie International Edition, 2008; 47(12): 2222-2226.
Angelos, S. Yang, Y. W. Patel, K. Stoddart, J. F. Zink, J. I.   pH-responsive supramolecular nanovalves based on cucurbit[6]uril pseudorotaxanes Angewandte Chemie-International Edition, 2008; 47(12): 2222-2226.
Ow, F. P. Djurovich, P. I. Thompson, M. E. Zink, J. I.   Wavelength-dependent photofragmentation of a mixed-ligand cyclometalated Platinum(II) coordination compound in a molecular beam Inorganic Chemistry, 2008; 47(7): 2389-2395.
Angelos, S. Liong, M. Choi, E. Zink, J. I.   Mesoporous silicate materials as substrates for molecular machines and drug delivery Chemical Engineering Journal, 2008; 137(1): 4-13.
Patel, K. Angelos, S. Dichtel, W. R. Coskun, A. Yang, Y. W. Zink, J. I. Stoddart, J. F.   Enzyme-responsive snap-top covered silica nanocontainers Journal of the American Chemical Society, 2008; 130(8): 2382-2383.
S.F. Nelsen, A.E. Konradsson, M.N. Weaver, R. M. Stephenson, J. V. Lockard, Y.Zhao, and J.I. Zink   Comparisons of Measured Rate Constants with Spectroscopically Determined Electron-Transfer Parameters J.Phys.Chem. B, 2007; 111: 6776-6781 .
T.D. Nguyen, Y. Liu, S. Saha, K.C.-F. Leung, J.F. Stoddart, and J.I. Zink   Design and Optimization of Molecular Nanovalves Based on Redox-Switchable Bistable Rotaxanes J. Am. Chem. Soc, 2007; 129: 626-634.
X. Wang, J. Li, M.E. Thompson, and J.I. Zink   Excited-State Distortions of Cyclometalated Ir (III) Complexes Determined from the Vibronic Structure in Luminescence Spectra J. Am. Chem. Soc, 2007; 111: 3256-3262 .
J. Lu, M. Liong, J. Zink, and F. Tamanoi   Mesoporous Silica Nanoparticles as a Delivery System for Hydrophobic Anticancer Drugs Small, 2007; 3: 1341-1346 .
S. Angelos, E. Johansson, J.F. Stoddart, and J.I. Zink   Mesostructured Silica Supports for Functional Materials and Molecular Machines Adv. Funct. Mater, 2007; 17: 2261-2271.
B. Dunn and J.I. Zink   Molecules in Glass: Probes, Ordered Assemblies, and Functional Materials Acc. Chem. Res, 2007; 40: 747-755.
F. P. Ow, B. Henderson, and J.I. Zink   Multiple Photochemical Reaction Pathways in a Ni(II) Coordination Compound Inorg. Chem, 2007; 46: 2243-2248.
E. Johansson and J. I. Zink   Nanostructured Silica Thin Films Self-Assembled with Electron Donors and Acceptors to Measure Electron Tunneling J. Am. Chem. Soc, 2007; 129: 14437-14443.
S. Saha, K.C.F. Leung, T. Nguyen, J.F. Stoddart, and J.I. Zink   Nanovalves Adv. Funct. Mater, 2007; 17: 685-693.
S. Angelos, E. Choi, F. Vogtle, L. DeCola, and J.I. Zink   Photo-Driven Expulsion of Molecules from Mesostructure /Silica Nanoparticles J.Phys.Chem. C, 2007; 111: 6587-6592.
X.Wang, G.Valverde-Aguilar, M. N. Weaver, S. F. Nelsen, and J.I. Zink   Resonance Raman De-Enhancement Caused by Exited State Mixed Valence J. Phys. Chem. A, 2007; 111: 5441-5447.
T.D. Nguyen, K.C.F. Leung, M. Liong, Y. Liu, J.F. Stoddart, and J.I. Zink   Versatile Supramolecular Nanovalves Reconfigured for Light Activation Adv. Funct. Mater, 2007; 17: 2101-2110.
F.P. Ow, M.T. Berry, P.S. May, and J.I. Zink   Wavelength and Metal Dependence in the Photofragmentation of a Gas-Phase Lanthanide B-Diketonate Complex J. Phys. Chem. A, 2007; 111: 4144-4149.
T.D. Ngyuen, K. C.-F. Leung, M. Liong, C.D. Pentecost, J.F. Stoddart and J.I. Zink   Construction of a pH-Driven Supramolecular Nanovalve Org. Lett, 2006; 8: 3363-3366 .
E.A. Plummer, J.I. Zink   Excited-State Mixed Valence in Transition Metal Complexes Inorganic Chemistry, 2006; 45(17): 6556-6558.
J.V. Lockard, J.I. Zink, Y. Luo, M.N. Weaver, J.W. Fowble, A.E. Konradsson, and S.F. Nelsen   Excited-State Mixed-Valence Distortions in a Diisopropyl Diphenyl Hydrazine Cation J. Am. Chem. Soc, 2006; 128(51): 16524-16531.
Lockard, J. V.; Valverde, G.; Neuhauser, D.; Zink, J. I.; Luo, Y.; Weaver, M. N.; Nelsen, S. F.   Interpretation of Unusual Absorption Bandwidths and Resonance Raman Intensities in Excited State Mixed Valence Journal of Physical Chemistry A, 2006; 110(1): 57-66.
S.F. Nelsen, Y. Luo, M.N. Weaver, J.V. Lockard, and J.I. Zink   Optical Spectra of Protected Diamine 10-Bond-Bridged Intervalence Radical Cations Related to N,N,N’N’-Tetraalkylbenzidine J. Org. Chem, 2006; 71: 4286-4295 .
S.F. Nelson, A.E. Konradsson, M.N. Weaver, N. Michael, I.A. Guzei, M. Gobel, R. Wortmann, J.V. Lockard and J.I. Zink   Photochemical Charge Separation within Aromatic Hydrazines and the Effect of Excited-State Intervalence Dihydrazines J. Phys. Chem. A, 2006; 109: 10854-10861.
G. Valverde-Aguilar, X. Wang, S.F. Nelsen and J.I. Zink   Photoinduced Electron Transfer in 2-tert-Butyl-3-(Anthracen-9-yl)-2,3-Diazabicyclo[2.2.2]Octane J. Am. Chem. Soc, 2006; 128: 6180-6185 .
P. Sierocki, H. Maas, P. Dragut, G. Richardt, F. Voegtle, L. De Cola, F. Brower and J. I. Zink   Photoisomerization of Azobenzene Derivatives in Nanostructured Silica J. Phys. Chem. B, 2006; 110: 24390-24398 .
K. C.-F. Leung, T. D. Ngyuen, J.F. Stoddart and J.I. Zink   Supramolecular Nanovalves Controlled by Proton Abstraction and Competitive Binding Chem. Mater, 2006; 18: 5919-5928.
M.J. Poderycki, V.A. Kickhoefer, C.S. Kaddis, S. Ravel-Fernandes, E. Johansson, and J.I. Zink   The Vault Exterior Shell is a Dynamic Structure that Allows Incorporation of Vault-Associated Proteins into its Interior Biochem, 2006; 45: 12184.
S.F. Nelsen, M.N. Weaver, Y. Luo, J.V. Lockard and J.I. Zink   Use of the Neighboring Orbital Model for Analysis of Electronic Coupling in Class III Intervalence Compounds Chemical Physics, 2006; 324: 195-201 .
Saha, S.; Johansson, E.; Flood, A. H.; Tseng, H.-R.; Zink, J. I.; Stoddart, J. F.   A photoactive molecular triad as a nanoscale power supply for a supramolecular machine Chemistry, 2005; 11(23): 6846-58.
Nguyen, T. D.; Tseng, H.-R.; Celestre, P. C.; Flood, A. H.; Liu, Y.; Stoddart, J. F.; Zink, J. I.   A reversible molecular valve PNAS, 2005; 102(29): 10029-10034.
Lockard, J. V.; Zink, J. I.; Trieber, D. A., II; Konradsson, A. E.; Weaver, M. N.; Nelsen, S. F.   Excited-State Mixed Valence in a Diphenyl Hydrazine Cation: Spectroscopic Consequences of Coupling and Transition Dipole Moment Orientation Journal of Physical Chemistry A, 2005; 109(6): 1205-1215.
Hsueh, H.-S.; Yang, C.-T.; Zink, J. I.; Huang, M. H.   Formation of Titanium Nitride Nanoparticles within Mesoporous Silica SBA-15 Journal of Physical Chemistry B, 2005; 109(10): 4404-4409.
Minoofar, P. N.; Dunn, B. S.; Zink, J. I.   Multiply Doped Nanostructured Silicate Sol-Gel Thin Films: Spatial Segregation of Dopants, Energy Transfer, and Distance Measurements Journal of the American Chemical Society, 2005; 127(8): 2656-2665.
Lan, E. H.; Dunn, B.; Zink, J. I.   Nanostructured systems for biological materials Methods in Molecular Biology, 2005; 300: 53-79.
Saha, S.; Johansson, L. E.; Flood, A. H.; Tseng, H.-R.; Zink, J. I.; Stoddart, J. F.   Powering a supramolecular machine with a photoactive molecular triad Small , 2005; 1(1): 87-90.
Kickhoefer, VA Garcia, Y Mikyas, Y Johansson, E Zhou, JC Raval-Fernandes, S Minoofar, P Zink, JI Dunn, B Stewart, PL Rome, LH   Engineering of vault nanocapsules with enzymatic and fluorescent properties PNAS, 2005; 102(12): 4348-52.
R. Hernandez, H.R. Tseng, J.W. Wong, J.F. Stoddart, J.I. Zink   An Operational Supramolecule Nanovalve J. Am. Chem. Soc, 2004; 126: 3370-3371.
Hawthorne, M. F.; Zink, J. I.; Skelton, J. M.; Bayer, M. J.; Liu, C.; Livshits, E.; Baer, R.; Neuhauser, D.   Electrical or Photocontrol of the Rotary Motion of a Metallacarborane Science, 2004; 303(5665): 1849-1851.
Rickus, J. L.; Chang, P. L.; Tobin, A. J.; Zink, J. I.; Dunn, B.   Photochemical Coenzyme Regeneration in an Enzymatically Active Optical Material Journal of Physical Chemistry B, 2004; 108(26): 9325-9332.
Bussiere, G., C. Reber, D. Neuhauser, D.A. Walter, and J.I. Zink   Molecular properties obtained by analysis of electronic spectra containing interference dips. Comparisons of analytical equations and exact models based on coupled potential energy surfaces Journal of Physical Chemistry A, 2003; 107(9): 1258-1267.
Lockard, J.V., J.I. Zink, A.E. Konradsson, M.N. Weaver, and S.F. Nelsen   Spectroscopic consequences of a mixed valence excited state: Quantitative treatment of a dihydrazine diradical dication Journal of the American Chemical Society, 2003; 125(44): 13471-13480.

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