Manuel Penichet, M.D., Ph.D.
Work Phone Number:
Factor Bldg 12-228
10833 Le Conte Ave.
BOX 951782, 54-117 CHS
Los Angeles, CA 90095
Microbiology, Immunology & Molecular Genetics
ACCESS Program: MBI IDP
JCCC Tumor Immunology Program Area
Molecular Biology IDP
A Short Biography:
Penichet, who holds an M.D. and a doctorate in biochemistry from the Havana Advanced Institute of Medical Sciences, worked on the development of a recombinant vaccine against cattle ticks in Cuba. Since then, it has been marketed and used internationally.
In 1993, Penichet left Cuba to conduct research as a postdoctoral fellow with the Institute of Genetic Biochemistry and Evolution in Pavia, Italy. He came to UCLA in 1996 as a postdoctoral fellow in the Department of Microbiology, Immunology and Molecular Genetics under the mentorship of Professor Sherie Morrison.
In addition to his success at mentoring students, Penichet is frequently invited to serve as a keynote speaker at international meetings and institutions. He has published in such prestigious medical journals as Proceedings of the National Academy of Sciences, U.S.A., and has served as a consultant to the National Cancer Institute to implement a strategy to reduce the health disparities in cancer treatment between minority populations and other ethnic groups in the United States.
Daniels-Wells Tracy R, Helguera Gustavo, Leuchter Richard K, Quintero Rafaela, Kozman Maggie, Rodríguez José A, Ortiz-Sánchez Elizabeth, Martínez-Maza Otoniel, Schultes Birgit C, Nicodemus Christopher F, Penichet Manuel L
A novel IgE antibody targeting the prostate-specific antigen as a
potential prostate cancer therapy.
Daniels-Wells Tracy R, Helguera Gustavo, Rodríguez José A, Leoh Lai Sum, Erb Michael A, Diamante Graciel, Casero David, Pellegrini Matteo, Martínez-Maza Otoniel, Penichet Manuel L
Insights into the mechanism of cell death induced by saporin delivered
into cancer cells by an antibody fusion protein targeting the
transferrin receptor 1.
Toxicology in vitro : an international journal published in association with BIBRA,
Daniels Tracy R, Leuchter Richard K, Quintero Rafaela, Helguera Gustavo, Rodríguez José A, Martínez-Maza Otoniel, Schultes Birgit C, Nicodemus Christopher F, Penichet Manuel L
Targeting HER2/neu with a fully human IgE to harness the allergic
reaction against cancer cells.
Cancer immunology, immunotherapy : CII,
Daniels Tracy R, Bernabeu Ezequiel, Rodríguez José A, Patel Shabnum, Kozman Maggie, Chiappetta Diego A, Holler Eggehard, Ljubimova Julia Y, Helguera Gustavo, Penichet Manuel L
The transferrin receptor and the targeted delivery of therapeutic
agents against cancer.
Biochimica et biophysica acta,
Rodríguez José A, Luria-Pérez Rosendo, López-Valdés Héctor E, Casero David, Daniels Tracy R, Patel Shabnum, Avila David, Leuchter Richard, So Sokuntheavy, Ortiz-Sánchez Elizabeth, Bonavida Benjamin, Martínez-Maza Otoniel, Charles Andrew C, Pellegrini Matteo, Helguera Gustavo, Penichet Manuel L
Lethal iron deprivation induced by non-neutralizing antibodies
targeting transferrin receptor 1 in malignant B cells.
Leukemia & lymphoma,
Inoue Satoshi, Ding Hui, Portilla-Arias Jose, Hu Jinwei, Konda Bindu, Fujita Manabu, Espinoza Andres, Suhane Sonal, Riley Marisa, Gates Marcus, Patil Rameshwar, Penichet Manuel L, Ljubimov Alexander V, Black Keith L, Holler Eggehard, Ljubimova Julia Y
Polymalic acid-based nanobiopolymer provides efficient systemic breast
cancer treatment by inhibiting both HER2/neu receptor synthesis and
Rodríguez Jose A, Lopez Miguel A, Thayer Michelle C, Zhao Yunzhe, Oberholzer Michael, Chang Donald D, Kisalu Neville K, Penichet Manuel L, Helguera Gustavo, Bruinsma Robijn, Hill Kent L, Miao Jianwei
Propulsion of African trypanosomes is driven by bihelical waves with
alternating chirality separated by kinks.
Proceedings of the National Academy of Sciences of the United States of America,
Baritaki Stavroula, Suzuki Eriko, Umezawa Kazuo, Spandidos Demetrios A, Berenson James, Daniels Tracy R, Penichet Manuel L, Jazirehi Ali R, Palladino Michael, Bonavida Benjamin
Inhibition of Yin Yang 1-dependent repressor activity of DR5
transcription and expression by the novel proteasome inhibitor
NPI-0052 contributes to its TRAIL-enhanced apoptosis in cancer cells.
Journal of immunology (Baltimore, Md. : 1950),
Fujita Manabu, Lee Bong-Seop, Khazenzon Natalya M, Penichet Manuel L, Wawrowsky Kolja A, Patil Rameshwar, Ding Hui, Holler Eggehard, Black Keith L, Ljubimova Julia Y
Brain tumor tandem targeting using a combination of monoclonal
antibodies attached to biopoly(beta-L-malic acid).
Journal of controlled release : official journal of the Controlled Release Society,
Shi Yijiang, Reiman Tony, Li Weiqun, Maxwell Christopher A, Sen Subrata, Pilarski Linda, Daniels Tracy R, Penichet Manuel L, Feldman Rick, Lichtenstein Alan
Targeting aurora kinases as therapy in multiple myeloma.
Yoo Esther M, Chintalacharuvu Koteswara R, Penichet Manuel L, Morrison Sherie L
Myeloma expression systems.
Journal of immunological methods,