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Manuel Penichet, M.D., Ph.D.

Contact Information:

Fax Number:

310-825-7575

Work Phone Number:

(310) 206-5126
310-825-0457
310-825-1304

Office Address:

Factor Bldg 12-228

UNITED STATES

Work Address:

UCLA Surgery
10833 Le Conte Ave.
BOX 951782, 54-117 CHS
Los Angeles, CA 90095
UNITED STATES

Work Email Address:

penichet@mednet.ucla.edu

Website:

  

Home Page:

     Web-Profile


Associate Professor, Surgery

Microbiology, Immunology & Molecular Genetics

Member, ACCESS Program: MBI IDP

JCCC Tumor Immunology Program Area

CTSI

Faculty, Molecular Biology IDP

A Short Biography:

Penichet, who holds an M.D. and a doctorate in biochemistry from the Havana Advanced Institute of Medical Sciences, worked on the development of a recombinant vaccine against cattle ticks in Cuba. Since then, it has been marketed and used internationally. In 1993, Penichet left Cuba to conduct research as a postdoctoral fellow with the Institute of Genetic Biochemistry and Evolution in Pavia, Italy. He came to UCLA in 1996 as a postdoctoral fellow in the Department of Microbiology, Immunology and Molecular Genetics under the mentorship of Professor Sherie Morrison. In addition to his success at mentoring students, Penichet is frequently invited to serve as a keynote speaker at international meetings and institutions. He has published in such prestigious medical journals as Proceedings of the National Academy of Sciences, U.S.A., and has served as a consultant to the National Cancer Institute to implement a strategy to reduce the health disparities in cancer treatment between minority populations and other ethnic groups in the United States.

Publications:

Daniels-Wells Tracy R, Helguera Gustavo, Leuchter Richard K, Quintero Rafaela, Kozman Maggie, Rodríguez José A, Ortiz-Sánchez Elizabeth, Martínez-Maza Otoniel, Schultes Birgit C, Nicodemus Christopher F, Penichet Manuel L   A novel IgE antibody targeting the prostate-specific antigen as a potential prostate cancer therapy. BMC cancer, 2013; 13: 195.
Daniels-Wells Tracy R, Helguera Gustavo, Rodríguez José A, Leoh Lai Sum, Erb Michael A, Diamante Graciel, Casero David, Pellegrini Matteo, Martínez-Maza Otoniel, Penichet Manuel L   Insights into the mechanism of cell death induced by saporin delivered into cancer cells by an antibody fusion protein targeting the transferrin receptor 1. Toxicology in vitro : an international journal published in association with BIBRA, 2013; 27(1): 220-31.
Daniels Tracy R, Martínez-Maza Otoniel, Penichet Manuel L   Animal models for IgE-meditated cancer immunotherapy. Cancer immunology, immunotherapy : CII, 2012; 61(9): 1535-46.
Liu Hong, Tamashiro Samantha, Baritaki Stavroula, Penichet Manuel, Yu Youhua, Chen Haiming, Berenson James, Bonavida Benjamin   TRAF6 activation in multiple myeloma: a potential therapeutic target. Clinical lymphoma, myeloma & leukemia, 2012; 12(3): 155-63.
Daniels Tracy R, Leuchter Richard K, Quintero Rafaela, Helguera Gustavo, Rodríguez José A, Martínez-Maza Otoniel, Schultes Birgit C, Nicodemus Christopher F, Penichet Manuel L   Targeting HER2/neu with a fully human IgE to harness the allergic reaction against cancer cells. Cancer immunology, immunotherapy : CII, 2012; 61(7): 991-1003.
Daniels Tracy R, Bernabeu Ezequiel, Rodríguez José A, Patel Shabnum, Kozman Maggie, Chiappetta Diego A, Holler Eggehard, Ljubimova Julia Y, Helguera Gustavo, Penichet Manuel L   The transferrin receptor and the targeted delivery of therapeutic agents against cancer. Biochimica et biophysica acta, 2012; 1820(3): 291-317.
Daniels Tracy R, Ortiz-Sánchez Elizabeth, Luria-Pérez Rosendo, Quintero Rafaela, Helguera Gustavo, Bonavida Benjamin, Martínez-Maza Otoniel, Penichet Manuel L   An antibody-based multifaceted approach targeting the human transferrin receptor for the treatment of B-cell malignancies. Journal of immunotherapy (Hagerstown, Md. : 1997), 2011; 34(6): 500-8.
Rodríguez José A, Luria-Pérez Rosendo, López-Valdés Héctor E, Casero David, Daniels Tracy R, Patel Shabnum, Avila David, Leuchter Richard, So Sokuntheavy, Ortiz-Sánchez Elizabeth, Bonavida Benjamin, Martínez-Maza Otoniel, Charles Andrew C, Pellegrini Matteo, Helguera Gustavo, Penichet Manuel L   Lethal iron deprivation induced by non-neutralizing antibodies targeting transferrin receptor 1 in malignant B cells. Leukemia & lymphoma, 2011; 52(11): 2169-78.
Inoue Satoshi, Ding Hui, Portilla-Arias Jose, Hu Jinwei, Konda Bindu, Fujita Manabu, Espinoza Andres, Suhane Sonal, Riley Marisa, Gates Marcus, Patil Rameshwar, Penichet Manuel L, Ljubimov Alexander V, Black Keith L, Holler Eggehard, Ljubimova Julia Y   Polymalic acid-based nanobiopolymer provides efficient systemic breast cancer treatment by inhibiting both HER2/neu receptor synthesis and activity. Cancer research, 2011; 71(4): 1454-64.
Helguera Gustavo, Rodríguez José A, Luria-Pérez Rosendo, Henery Shannon, Catterton Paul, Bregni Carlos, George Thaddeus C, Martínez-Maza Otoniel, Penichet Manuel L   Visualization and quantification of cytotoxicity mediated by antibodies using imaging flow cytometry. Journal of immunological methods, 2011; 368(1-2): 54-63.
Morizono Kouki, Xie Yiming, Helguera Gustavo, Daniels Tracy R, Lane Timothy F, Penichet Manuel L, Chen Irvin S Y   A versatile targeting system with lentiviral vectors bearing the biotin-adaptor peptide. The journal of gene medicine, 2009; 11(8): 655-63.
Rodríguez Jose A, Lopez Miguel A, Thayer Michelle C, Zhao Yunzhe, Oberholzer Michael, Chang Donald D, Kisalu Neville K, Penichet Manuel L, Helguera Gustavo, Bruinsma Robijn, Hill Kent L, Miao Jianwei   Propulsion of African trypanosomes is driven by bihelical waves with alternating chirality separated by kinks. Proceedings of the National Academy of Sciences of the United States of America, 2009; 106(46): 19322-7.
Montano Ramon F, Penichet Manuel L, Blackall Douglas P, Morrison Sherie L, Chintalacharuvu Koteswara R   Recombinant polymeric IgG anti-Rh: a novel strategy for development of direct agglutinating reagents. Journal of immunological methods, 2009; 340(1): 1-10.
Ortiz-Sánchez Elizabeth, Helguera Gustavo, Daniels Tracy R, Penichet Manuel L   Antibody-cytokine fusion proteins: applications in cancer therapy. Expert opinion on biological therapy, 2008; 8(5): 609-32.
Baritaki Stavroula, Suzuki Eriko, Umezawa Kazuo, Spandidos Demetrios A, Berenson James, Daniels Tracy R, Penichet Manuel L, Jazirehi Ali R, Palladino Michael, Bonavida Benjamin   Inhibition of Yin Yang 1-dependent repressor activity of DR5 transcription and expression by the novel proteasome inhibitor NPI-0052 contributes to its TRAIL-enhanced apoptosis in cancer cells. Journal of immunology (Baltimore, Md. : 1950), 2008; 180(9): 6199-210.
Rodríguez José A, Helguera Gustavo, Daniels Tracy R, Neacato Isabel I, López-Valdés Héctor E, Charles Andrew C, Penichet Manuel L   Binding specificity and internalization properties of an antibody-avidin fusion protein targeting the human transferrin receptor. Journal of controlled release : official journal of the Controlled Release Society, 2007; 124(1-2): 35-42.
Fujita Manabu, Lee Bong-Seop, Khazenzon Natalya M, Penichet Manuel L, Wawrowsky Kolja A, Patil Rameshwar, Ding Hui, Holler Eggehard, Black Keith L, Ljubimova Julia Y   Brain tumor tandem targeting using a combination of monoclonal antibodies attached to biopoly(beta-L-malic acid). Journal of controlled release : official journal of the Controlled Release Society, 2007; 122(3): 356-63.
Daniels Tracy R, Ng Patrick P, Delgado Tracie, Lynch Maureen R, Schiller Gary, Helguera Gustavo, Penichet Manuel L   Conjugation of an anti transferrin receptor IgG3-avidin fusion protein with biotinylated saporin results in significant enhancement of its cytotoxicity against malignant hematopoietic cells. Molecular cancer therapeutics, 2007; 6(11): 2995-3008.
Helguera Gustavo, Rodríguez José A, Daniels Tracy R, Penichet Manuel L   Long-term immunity elicited by antibody-cytokine fusion proteins protects against sequential challenge with murine mammary and colon malignancies. Cancer immunology, immunotherapy : CII, 2007; 56(9): 1507-12.
Shi Yijiang, Reiman Tony, Li Weiqun, Maxwell Christopher A, Sen Subrata, Pilarski Linda, Daniels Tracy R, Penichet Manuel L, Feldman Rick, Lichtenstein Alan   Targeting aurora kinases as therapy in multiple myeloma. Blood, 2007; 109(9): 3915-21.
Dela Cruz Jay Soriano, Trinh Kamh Ryan, Chen Hsiao Wen, Ribas Antoni, Morrison Sherie L, Penichet Manuel L   Anti-HER2/neu IgG3-(IL-2) and anti-HER2/neu IgG3-(GM-CSF) promote HER2/neu processing and presentation by dendritic cells: implications in immunotherapy and vaccination strategies. Molecular immunology, 2006; 43(6): 667-76.
Helguera Gustavo, Rodríguez José A, Penichet Manuel L   Cytokines fused to antibodies and their combinations as therapeutic agents against different peritoneal HER2/neu expressing tumors. Molecular cancer therapeutics, 2006; 5(4): 1029-40.
Ng Patrick P, Helguera Gustavo, Daniels Tracy R, Lomas Simon Z, Rodriguez Jose A, Schiller Gary, Bonavida Benjamin, Morrison Sherie L, Penichet Manuel L   Molecular events contributing to cell death in malignant human hematopoietic cells elicited by an IgG3-avidin fusion protein targeting the transferrin receptor. Blood, 2006; 108(8): 2745-54.
Daniels Tracy R, Delgado Tracie, Rodriguez Jose A, Helguera Gustavo, Penichet Manuel L   The transferrin receptor part I: Biology and targeting with cytotoxic antibodies for the treatment of cancer. Clinical immunology (Orlando, Fla.), 2006; 121(2): 144-58.
Daniels Tracy R, Delgado Tracie, Helguera Gustavo, Penichet Manuel L   The transferrin receptor part II: targeted delivery of therapeutic agents into cancer cells. Clinical immunology (Orlando, Fla.), 2006; 121(2): 159-76.
Helguera Gustavo, Dela Cruz Jay S, Lowe Christine, Ng Patrick P, Trinh Ryan, Morrison Sherie L, Penichet Manuel L   Vaccination with novel combinations of anti-HER2/neu cytokines fusion proteins and soluble protein antigen elicits a protective immune response against HER2/neu expressing tumors. Vaccine, 2006; 24(3): 304-16.
Asai Tsuneaki, Trinh Ryan, Ng Patrick P, Penichet Manuel L, Wims Letitia A, Morrison Sherie L   A human biotin acceptor domain allows site-specific conjugation of an enzyme to an antibody-avidin fusion protein for targeted drug delivery. Biomolecular engineering, 2005; 21(6): 145-55.
Asai T, Trinh R, Ng PP, Penichet ML, Wims LA, Morrison SL   A human biotin acceptor domain allows site-specific conjugation of an enzyme to an antibody-avidin fusion protein for targeted drug delivery. Biomolecular engineering. , 2005; 21(6): 145-55.
Helguera G, Penichet ML   Antibody-cytokine fusion proteins for the therapy of cancer. Methods in molecular medicine. , 2005; 109: 347-74.
Helguera Gustavo, Penichet Manuel L   Antibody-cytokine fusion proteins for the therapy of cancer. Methods in molecular medicine, 2005; 109(6): 347-74.
Dela Cruz JS, Huang TH, Penichet ML, Morrison SL   Antibody-cytokine fusion proteins: innovative weapons in the war against cancer. Clinical and experimental medicine. , 2004; 4(2): 57-64.
Dela Cruz JS, Lau SY, Ramirez EM, De Giovanni C, Forni G, Morrison SL, Penichet ML   Protein vaccination with the HER2/neu extracellular domain plus anti-HER2/neu antibody-cytokine fusion proteins induces a protective anti-HER2/neu immune response in mice Vaccine, 2003; 21(13-14): 1317-26.
Dela Cruz Jay S, Lau Suk Ying, Ramirez Ernesto M, De Giovanni Carla, Forni Guido, Morrison Sherie L, Penichet Manuel L   Protein vaccination with the HER2/neu extracellular domain plus anti-HER2/neu antibody-cytokine fusion proteins induces a protective anti-HER2/neu immune response in mice. Vaccine, 2003; 21(13-14): 1317-26.
Ng Patrick P, Dela Cruz Jay S, Sorour David N, Stinebaugh James M, Shin Seung-Uon, Shin Daniel S, Morrison Sherie L, Penichet Manuel L   An anti-transferrin receptor-avidin fusion protein exhibits both strong proapoptotic activity and the ability to deliver various molecules into cancer cells. Proceedings of the National Academy of Sciences of the United States of America, 2002; 99(16): 10706-11.
Yoo Esther M, Chintalacharuvu Koteswara R, Penichet Manuel L, Morrison Sherie L   Myeloma expression systems. Journal of immunological methods, 2002; 261(1-2): 1-20.
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