Professor Benhur Lee is a virologist with wide-ranging research interests who is member of the Department of Microbiology, Immunology & Molecular Genetics as well as the Department of Pathology and Laboratory Medicine at the David Geffen School of Medicine (University of California, Los Angeles.) He joined UCLA in 2001 as an Assistant Professor, was promoted to Associate Professor in 2007, and full Professor in 2011. Dr. Lee obtained his M.D. from Yale University (1995), and did his clinical and post-doctoral training at the University of Pennsylvania Medical Center (1995-2001) where he also served as Chief Resident (1997). He worked on HIV fusion and entry during his post-doctoral years under Dr. Robert Doms (1997-2001). Dr. Lee is board-certified in Clinical Pathology and is also an attending physician on the Transfusion Medicine Service at the UCLA medical center. He is a member of the UCLA AIDS Institute and the Center for AIDS Research. Dr. Lee is a member of the MD/PhD (MSTP) admissions committee, and serves as the Affinity Group Leader and Graduate Advisor for students interested in Virology and Gene Therapy. He is Vice-Chair (Clinical and Translational efforts) of the training committee overseeing an NIH T32 training program in Virology & Gene Therapy, and is a standing member on the Embryonic Stem Cell Research Oversight Committee at UCLA. Dr. Lee believes in multidisciplinary approaches to science and currently has graduate students and post-docs whose primary expertise ranges across fields such as biomathematics, biophysics, biochemistry, cell biology, and molecular virology. He has a special interest in enveloped virus entry and budding mechanisms using HIV and emerging paramyxoviruses (henipaviruses) as model systems. In addition, he also has active projects translating insights gained from basic studies on host-pathogen interactions into broad-spectrum anti-viral therapeutics, and has access to BSL3 (UCLA) and BSL4 (UTMB-Galveston) facilities for high-containment work on lethal pathogens.
Pernet Olivier, Wang Yao E, Lee Benhur Henipavirus Receptor Usage and Tropism Current topics in microbiology and immunology, 2012; .
Lee Benhur Containing the contagion: treating the virus that inspired the film Science translational medicine, 2011; 3(105): 105fs6.
Lee Benhur, Ataman Zeynep Akyol Modes of paramyxovirus fusion: a Henipavirus perspective Trends in microbiology, 2011; 19(8): 389-99.
Aguilar Hector C, Lee Benhur Emerging paramyxoviruses: molecular mechanisms and antiviral strategies Expert reviews in molecular medicine, 2011; 13: e6.
Bi Shuguang, Hong Patrick W, Lee Benhur, Baum Linda G Galectin-9 binding to cell surface protein disulfide isomerase regulates the redox environment to enhance T-cell migration and HIV entry Proceedings of the National Academy of Sciences of the United States of America, 2011; 108(26): 10650-5.
Roche Michael, Jakobsen Martin R, Sterjovski Jasminka, Ellett Anne, Posta Filippo, Lee Benhur, Jubb Becky, Westby Mike, Lewin Sharon R, Ramsland Paul A, Churchill Melissa J, Gorry Paul R HIV-1 escape from the CCR5 antagonist maraviroc associated with an altered and less-efficient mechanism of gp120-CCR5 engagement that attenuates macrophage tropism Journal of virology, 2011; 85(9): 4330-42.
Mirza Anne M, Aguilar Hector C, Zhu Qiyun, Mahon Paul J, Rota Paul A, Lee Benhur, Iorio Ronald M Triggering of the newcastle disease virus fusion protein by a chimeric attachment protein that binds to Nipah virus receptors The Journal of biological chemistry, 2011; 286(20): 17851-60.
Morizono Kouki, Xie Yiming, Olafsen Tove, Lee Benhur, Dasgupta Asim, Wu Anna M, Chen Irvin S Y The soluble serum protein Gas6 bridges virion envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry Cell host & microbe, 2011; 9(4): 286-98.
Aguilar Hector C, Aspericueta Vanessa, Robinson Lindsey R, Aanensen Karen E, Lee Benhur A quantitative and kinetic fusion protein-triggering assay can discern distinct steps in the nipah virus membrane fusion cascade Journal of virology, 2010; 84(16): 8033-41.
Garner Omai B, Aguilar Hector C, Fulcher Jennifer A, Levroney Ernest L, Harrison Rebecca, Wright Lacey, Robinson Lindsey R, Aspericueta Vanessa, Panico Maria, Haslam Stuart M, Morris Howard R, Dell Anne, Lee Benhur, Baum Linda G Endothelial galectin-1 binds to specific glycans on nipah virus fusion protein and inhibits maturation, mobility, and function to block syncytia formation PLoS pathogens, 2010; 6(7): e1000993.
Wolf Mike C, Freiberg Alexander N, Zhang Tinghu, Akyol-Ataman Zeynep, Grock Andrew, Hong Patrick W, Li Jianrong, Watson Natalya F, Fang Angela Q, Aguilar Hector C, Porotto Matteo, Honko Anna N, Damoiseaux Robert, Miller John P, Woodson Sara E, Chantasirivisal Steven, Fontanes Vanessa, Negrete Oscar A, Krogstad Paul, Dasgupta Asim, Moscona Anne, Hensley Lisa E, Whelan Sean P, Faull Kym F, Holbrook Michael R, Jung Michael E, Lee Benhur A broad-spectrum antiviral targeting entry of enveloped viruses Proceedings of the National Academy of Sciences of the United States of America, 2010; 107(7): 3157-62.
Shimizu Saki, Hong Patrick, Arumugam Balamurugan, Pokomo Lauren, Boyer Joshua, Koizumi Naoya, Kittipongdaja Panyamol, Chen Angela, Bristol Greg, Galic Zoran, Zack Jerome A, Yang Otto, Chen Irvin S Y, Lee Benhur, An Dong Sung A highly efficient short hairpin RNA potently down-regulates CCR5 expression in systemic lymphoid organs in the hu-BLT mouse model Blood, 2010; 115(8): 1534-44.
Wang Yao E, Park Arnold, Lake Michael, Pentecost Mickey, Torres Betsabe, Yun Tatyana E, Wolf Mike C, Holbrook Michael R, Freiberg Alexander N, Lee Benhur Ubiquitin-regulated nuclear-cytoplasmic trafficking of the Nipah virus matrix protein is important for viral budding PLoS pathogens, 2010; 6(11): e1001186.
Johnston Samantha H, Lobritz Michael A, Nguyen Sandra, Lassen Kara, Delair Shirley, Posta Filippo, Bryson Yvonne J, Arts Eric J, Chou Tom, Lee Benhur A quantitative affinity-profiling system that reveals distinct CD4/CCR5 usage patterns among human immunodeficiency virus type 1 and simian immunodeficiency virus strains Journal of virology, 2009; 83(21): 11016-26.
Hashimi Sara T, Fulcher Jennifer A, Chang Margaret H, Gov Lanny, Wang Shuo, Lee Benhur MicroRNA profiling identifies miR-34a and miR-21 and their target genes JAG1 and WNT1 in the coordinate regulation of dendritic cell differentiation Blood, 2009; 114(2): 404-14.
Pugach Pavel, Ray Neelanjana, Klasse Per Johan, Ketas Thomas J, Michael Elizabeth, Doms Robert W, Lee Benhur, Moore John P Inefficient entry of vicriviroc-resistant HIV-1 via the inhibitor-CCR5 complex at low cell surface CCR5 densities Virology, 2009; 387(2): 296-302.
Lassen Kara G, Lobritz Michael A, Bailey Justin R, Johnston Samantha, Nguyen Sandra, Lee Benhur, Chou Tom, Siliciano Robert F, Markowitz Martin, Arts Eric J Elite suppressor-derived HIV-1 envelope glycoproteins exhibit reduced entry efficiency and kinetics PLoS pathogens, 2009; 5(4): e1000377.
Aguilar Hector C, Ataman Zeynep Akyol, Aspericueta Vanessa, Fang Angela Q, Stroud Matthew, Negrete Oscar A, Kammerer Richard A, Lee Benhur A novel receptor-induced activation site in the Nipah virus attachment glycoprotein (G) involved in triggering the fusion glycoprotein (F) The Journal of biological chemistry, 2009; 284(3): 1628-35.
Lee Benhur, Ataman Zeynep Akyol, Jin Lei Evil versus 'eph-ective' use of ephrin-B2 Nature structural & molecular biology, 2008; 15(6): 540-2.
Negrete Oscar A, Chu David, Aguilar Hector C, Lee Benhur Single amino acid changes in the Nipah and Hendra virus attachment glycoproteins distinguish ephrinB2 from ephrinB3 usage Journal of virology, 2007; 81(19): 10804-14.
Aguilar Hector C, Matreyek Kenneth A, Choi Daniel Y, Filone Claire Marie, Young Sophia, Lee Benhur Polybasic KKR motif in the cytoplasmic tail of Nipah virus fusion protein modulates membrane fusion by inside-out signaling Journal of virology, 2007; 81(9): 4520-32.
Fulcher Jennifer A, Hashimi Sara T, Levroney Ernest L, Pang Mabel, Gurney Kevin B, Baum Linda G, Lee Benhur Galectin-1-matured human monocyte-derived dendritic cells have enhanced migration through extracellular matrix Journal of immunology (Baltimore, Md. : 1950), 2006; 177(1): 216-26.
Aguilar Hector C, Matreyek Kenneth A, Filone Claire Marie, Hashimi Sara T, Levroney Ernest L, Negrete Oscar A, Bertolotti-Ciarlet Andrea, Choi Daniel Y, McHardy Ian, Fulcher Jennifer A, Su Stephen V, Wolf Mike C, Kohatsu Luciana, Baum Linda G, Lee Benhur N-glycans on Nipah virus fusion protein protect against neutralization but reduce membrane fusion and viral entry Journal of virology, 2006; 80(10): 4878-89.
Negrete Oscar A, Wolf Mike C, Aguilar Hector C, Enterlein Sven, Wang Wei, Mühlberger Elke, Su Stephen V, Bertolotti-Ciarlet Andrea, Flick Ramon, Lee Benhur Two key residues in ephrinB3 are critical for its use as an alternative receptor for Nipah virus PLoS pathogens, 2006; 2(2): e7.
Negrete OA, Levroney EL, Aguilar HC, Bertolotti-Ciarlet A, Nazarian R, Tajyar S, Lee B EphrinB2 is the entry receptor for Nipah virus, an emergent deadly paramyxovirus Nature. , 2005; 436(7049): 401-5.
Levroney EL, Aguilar HC, Fulcher JA, Kohatsu L, Pace KE, Pang M, Gurney KB, Baum LG, Lee B Novel innate immune functions for galectin-1: galectin-1 inhibits cell fusion by Nipah virus envelope glycoproteins and augments dendritic cell secretion of proinflammatory cytokines Journal of immunology (Baltimore, Md. : 1950) , 2005; 175(1): 413-20.
Gurney KB, Elliott J, Nassanian H, Song C, Soilleux E, McGowan I, Anton PA, Lee B Binding and transfer of human immunodeficiency virus by DC-SIGN+ cells in human rectal mucosa Journal of virology. , 2005; 79(9): 5762-73.
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