Publications:
A selected list of publications:
Hideaki Tsutsui*, Bahram Valamehr*, Antreas Hindoyan, Rong Qiao, Xianting Ding, Shuling Guo, Owen N. Witte, Xin Liu, Chih-Ming Ho & Hong Wu.
An optimized small molecule inhibitor cocktail supports long-term maintenance of human embryonic stem cells,
Nat Commun,
2011; 2:167:
1-8.
Goebbels, S., Oltrogge, J., Kemper, R., Heilmann, I., Wichert, S., Bormuth, I., Wolfer, S., Liu, X., Lappe-Siefke, C., Rossner, M., Groszer, M., Suter, U., Frahm, J., Boretius, S., and Nave, K.
Elevated phosphatidylinositol 3,4,5 trisphosphate in glia triggers cell autonomous membrane wrapping and myelination,
J. Neuroscience ,
2010; 30(26):
8953-64.
Gregorian Caroline, Nakashima Jonathan, Dry Sarah M, Nghiemphu P Leia, Smith Kate Barzan, Ao Yan, Dang Julie, Lawson Gregory, Mellinghoff Ingo K, Mischel Paul S, Phelps Michael, Parada Luis F, Liu Xin, Sofroniew Michael V, Eilber Fritz C, Wu Hong
PTEN dosage is essential for neurofibroma development and malignant
transformation
Proceedings of the National Academy of Sciences of the United States of America,
2009; 106(46):
19479-84.
Arikkah, J., Peng, F., Ng, Y., Israely, I., Liu, X., Ullian, E., Reichardt, L.
Delta-catenin regulates spine and synapse morphogenesis and function in hippocampal neurons,
J. Neuroscience,
2009; 29(17):
5435-5442.
Valamehr Bahram, Jonas Steven J, Polleux Julien, Qiao Rong, Guo Shuling, Gschweng Eric H, Stiles Bangyan, Kam Korey, Luo Tzy-Jiun M, Witte Owen N, Liu Xin, Dunn Bruce, Wu Hong
Hydrophobic surfaces for enhanced differentiation of embryonic stem
cell-derived embryoid bodies
Proceedings of the National Academy of Sciences of the United States of America,
2008; 105(38):
14459-64.
Arikkath, J., Israely, I., Tao, Y., Mei, L., Liu, X., and Reigardt, L
Erbin controls dendritic morphogenesis by regulating localization of -catenin,
J. Neuroscience,
2008; 28(28):
7047-7056.
Freeman Dan, Lesche Ralf, Kertesz Nathalie, Wang Shungyou, Li Gang, Gao Jing, Groszer Matthias, Martinez-Diaz Hilda, Rozengurt Nora, Thomas George, Liu Xin, Wu Hong
Genetic background controls tumor development in PTEN-deficient mice
Cancer research,
2006; 66(13):
6492-6.
Li, G., Hu, Y., Huo, Y., Liu, M., Freeman, D., Gao, J., Liu, X., Wu, DC., and Wu, H.
PTEN deletion leads to up-regulation of a secreted growth factor pleiotrophin. ,
J Biol Chem. ,
2006; 281(16):
10663-8.
Groszer, M., Erickson, R., Scripture-Adams, D., Dougherty, J., LeBelle, J., Zack, J., Geschwind, D., Liu, X., Kornblum, H., Wu, H.
PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry,
Proc. Natl. Acad. Sci. USA,
2006; 103:
111-116.
He, XP., Bulter, L., Liu, X., and McNamara, JO.
The tyrosine receptor kinase B ligand, neurotrophin-4, is not required for either epileptogenesis or tyrosine receptor kinase B activation in the kindling model,
Neuroscience,
2006; 141(1):
515-520.
Lei Qunying, Jiao Jing, Xin Li, Chang Chun-Ju, Wang Shunyou, Gao Jing, Gleave Martin E, Witte Owen N, Liu Xin, Wu Hong
NKX3.1 stabilizes p53, inhibits AKT activation, and blocks prostate
cancer initiation caused by PTEN loss
Cancer cell,
2006; 9(5):
367-78.
Nakano, I., Paucar, A., Bajpai, R., Dougherty, J., Zewail, A., Kim, K., Ou, J., Groszer, M., Imura, T., Freije, W., Nelson, S., Sofroniew, M., Wu, H., Liu, X., Terskikh, A., Geschwind, D., Kornblum, H.
Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation,
J. Cell Biol,
2005; 170:
413-427.
Israely I, Costa RM, Xie CW, Silva AJ, Kosik K and Liu X
The neuronal specific protein Delta-Catenin is essential for cognitive function. ,
Current Biology,
2004; 14 (18):
1657-1663.
Colwell CS, Michel S, Itri J, Rodriguez W, Tam J, Lelievre V, Hu Z, Liu X, Waschek JA
Disrupted circadian rhythms in VIP- and PHI-deficient mice
American journal of physiology. Regulatory, integrative and comparative physiology. ,
2003; 285(5):
R939-49.
Wang S, Gao J, Lei Q, Rozengurt N, Pritchard C, Jiao J, Thomas GV, Li G, Roy-Burman P, Nelson PS, Liu X, Wu H
Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer
Cancer cell. ,
2003; 4(3):
209-21.
Li G, Robinson GW, Lesche R, Martinez-Diaz H, Jiang Z, Rozengurt N, Wagner KU, Wu DC, Lane TF, Liu X, Hennighausen L, Wu H
Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland
Development (Cambridge, England) ,
2002; 129(17):
4159-70.
Lesche R, Groszer M, Gao J, Wang Y, Messing A, Liu X and Wu H
Cre/loxp-Mediated Inactivation of The Murine Pten Tumor Suppressor Gene,
Genesis,
2002; 32:
148-149.
Xie CW, Sayah D, Chen QS, Wei Wz, Smith D and Liu X
Deficient long-term memory and long-term potentiation with a targeted null mutation in neurotrophin-4 gene,
Proc. Natl. Acad. Sci. USA ,
2000; 97:
8116-8121.
Endres M, Fan GP, Hirt L, Fujii M, Liu X, Jaenisch R, Moskowitz MA
Ischemic brain damage in mice after selectively modifying BDNF or NT4 gene expression,
Journal of Cerebral Blood Flow and Metabolism ,
2000; 20(1):
139-144.
Sun H, Lesche R, Li Dm, Liliental J, Zhang H, Gao J, Gavriola N, Mueller B, Liu X, and Wu H
PTEN Modulates Cell Cycle Progression and Cell Survival by Regulating Phosphatidylinositol 3,4,5,-Triphophate and Akt/Protein Kinase B Signaling Pathway,
PNAS,
1999; 96:
6199-6204.
Byrne M, Eeckhout Y, Henriet P, Lemaitre V, Jeffrey JJ, Witter J, Liu X, Wu H, Jaenisch R and Krane SM
Different collagenase gene products have different roles in degradation of type I collagen,
J. Biol. Chem. ,
1996; 271:
28509-28515.
Wu H, Liu X, Jaenisch R and Lodish H
Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor,
Cell,
1995; 83:
59-67.
Liu X, Enfors P, Wu H and Jaenisch R
Sensory but not motor neuron deficits in mice lacking NT4 and BDNF,
Nature,
1995; 375:
238-241.
Wu H, Liu X and Jaenisch R
Double Replacement: A Strategy for Efficient Introduction of Subtle Mutations into Col1a1 gene by Homologous Recombination in ES Cells,
Proc. Natl. Acad. Sci. USA,
1994; 91:
2819-2823.
Zwieble L, Hardin P, Liu X, Hall J and Rosbash M
A post-transcriptional mechanism contributes to circadian cycling of per-b-galactosidase fusion protein,
Proc. Natl. Acad. Sci. USA ,
1991; 88:
3882-3886.
Liu X, Lorenz L, Yu Q, Hall J and Rosbash M
Spatial and temporal expression of the period gene in Drosophila melanogaster,
Genes Dev. ,
1988; 2:
228-238.