Andrea L Hevener

Title(s)Professor-in-Residence, Medicine
SchoolMedicine
ORCID ORCID Icon0000-0003-1508-4377 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Pepperdine University, Malibu, CABS04/1990Sports Medicine
    University of Southern California, Los AngelesPhD05/1998Kinesiology / Physiology & Biophysics

    Collapse Overview 
    Collapse Overview
    Dr. Andrea Hevener holds the Sidney Roberts and Clara Szego Roberts Endowed Chair in Molecular/Cellular Endocrinology.

    Collapse Research 
    Collapse Research Activities and Funding
    The impact of ERalpha on mitochondrial function in macrophages
    NIH R01DK128957Apr 1, 2021 - Mar 31, 2025
    Role: Principal Investigator
    Systems-based approaches for investigating tissue communication during exercise
    NIH U01AG070959Sep 30, 2020 - May 31, 2023
    Role: Principal Investigator
    Mechanisms controlling skeletal muscle mitochondrial function and metabolic health
    NIH R01DK109724Apr 15, 2016 - Mar 31, 2021
    Role: Principal Investigator
    ERalpha and the metabolic syndrome
    NIH R01DK089109Aug 15, 2011 - Jun 30, 2015
    Role: Principal Investigator
    The Impact of Heat Shock Protein Expression on Inflammation and Insulin Action
    NIH R01DK078760May 11, 2009 - Feb 28, 2014
    Role: Principal Investigator
    The impact of PPAR-gamma and estrogen receptor crosstalk on insulin action
    NIH R21DK073227Sep 30, 2006 - Aug 31, 2009
    Role: Principal Investigator
    The Role of PPAR-gamma Expression on Insulin Action
    NIH K01DK060484Feb 15, 2002 - Jan 31, 2007
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Drp1 controls complex II assembly and skeletal muscle metabolism by Sdhaf2 action on mitochondria. Sci Adv. 2024 Apr 05; 10(14):eadl0389. Zhou Z, Ma A, Moore TM, Wolf DM, Yang N, Tran P, Segawa M, Strumwasser AR, Ren W, Fu K, Wanagat J, van der Bliek AM, Crosbie-Watson R, Liesa M, Stiles L, Acin-Perez R, Mahata S, Shirihai O, Goodarzi MO, Handzlik M, Metallo CM, Walker DW, Hevener AL. PMID: 38569044; PMCID: PMC10990287.
      View in: PubMed   Mentions:    Fields:    
    2. Leveraging inter-individual transcriptional correlation structure to infer discrete signaling mechanisms across metabolic tissues. Elife. 2024 Jan 15; 12. Zhou M, Tamburini I, Van C, Molendijk J, Nguyen CM, Chang IY, Johnson C, Velez LM, Cheon Y, Yeo R, Bae H, Le J, Larson N, Pulido R, Nascimento-Filho CHV, Jang C, Marazzi I, Justice J, Pannunzio N, Hevener AL, Sparks L, Kershaw EE, Nicholas D, Parker BL, Masri S, Seldin MM. PMID: 38224289; PMCID: PMC10945578.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Leveraging inter-individual transcriptional correlation structure to infer discrete signaling mechanisms across metabolic tissues. bioRxiv. 2023 Oct 04. Zhou M, Tamburini IJ, Van C, Molendijk J, Nguyen CM, Chang IY, Johnson C, Velez LM, Cheon Y, Yeo RX, Bae H, Le J, Larson N, Pulido R, Filho C, Jang C, Marazzi I, Justice JN, Pannunzio N, Hevener A, Sparks LM, Kershaw EE, Nicholas D, Parker B, Masri S, Seldin M. PMID: 37214953; PMCID: PMC10197628.
      View in: PubMed   Mentions:
    4. Conserved multi-tissue transcriptomic adaptations to exercise training in humans and mice. Cell Rep. 2023 05 30; 42(5):112499. Moore TM, Lee S, Olsen T, Morselli M, Strumwasser AR, Lin AJ, Zhou Z, Abrishami A, Garcia SM, Bribiesca J, Cory K, Whitney K, Ho T, Ho T, Lee JL, Rucker DH, Nguyen CQA, Anand ATS, Yackly A, Mendoza LQ, Leyva BK, Aliman C, Artiga DJ, Meng Y, Charugundla S, Pan C, Jedian V, Seldin MM, Ahn IS, Diamante G, Blencowe M, Yang X, Mouisel E, Pellegrini M, Turcotte LP, Birkeland KI, Norheim F, Drevon CA, Lusis AJ, Hevener AL. PMID: 37178122.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    5. The mitochondrial multi-omic response to exercise training across tissues. bioRxiv. 2023 Jan 13. Amar D, Gay NR, Jimenez-Morales D, Beltran PMJ, Ramaker ME, Raja AN, Zhao B, Sun Y, Marwaha S, Gaul D, Hershman SG, Xia A, Lanza I, Fernandez FM, Montgomery SB, Hevener AL, Ashley EA, Walsh MJ, Sparks LM, Burant CF, Rector RS, Thyfault J, Wheeler MT, Goodpaster BH, Coen PM, Schenk S, Bodine SC, Lindholm ME, MoTrPAC Study Group. PMID: 36711881; PMCID: PMC9882193.
      View in: PubMed   Mentions:
    6. Parkin regulates adiposity by coordinating mitophagy with mitochondrial biogenesis in white adipocytes. Nat Commun. 2022 Nov 04; 13(1):6661. Moore TM, Cheng L, Wolf DM, Ngo J, Segawa M, Zhu X, Strumwasser AR, Cao Y, Clifford BL, Ma A, Scumpia P, Shirihai OS, Vallim TQA, Laakso M, Lusis AJ, Hevener AL, Zhou Z. PMID: 36333379; PMCID: PMC9636263.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    7. Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention. Nat Genet. 2022 09; 54(9):1332-1344. Wang Z, Emmerich A, Pillon NJ, Moore T, Hemerich D, Cornelis MC, Mazzaferro E, Broos S, Ahluwalia TS, Bartz TM, Bentley AR, Bielak LF, Chong M, Chu AY, Berry D, Dorajoo R, Dueker ND, Kasbohm E, Feenstra B, Feitosa MF, Gieger C, Graff M, Hall LM, Haller T, Hartwig FP, Hillis DA, Huikari V, Heard-Costa N, Holzapfel C, Jackson AU, Johansson Å, Jørgensen AM, Kaakinen MA, Karlsson R, Kerr KF, Kim B, Koolhaas CM, Kutalik Z, Lagou V, Lind PA, Lorentzon M, Lyytikäinen LP, Mangino M, Metzendorf C, Monroe KR, Pacolet A, Pérusse L, Pool R, Richmond RC, Rivera NV, Robiou-du-Pont S, Schraut KE, Schulz CA, Stringham HM, Tanaka T, Teumer A, Turman C, van der Most PJ, Vanmunster M, van Rooij FJA, van Vliet-Ostaptchouk JV, Zhang X, Zhao JH, Zhao W, Balkhiyarova Z, Balslev-Harder MN, Baumeister SE, Beilby J, Blangero J, Boomsma DI, Brage S, Braund PS, Brody JA, Bruinenberg M, Ekelund U, Liu CT, Cole JW, Collins FS, Cupples LA, Esko T, Enroth S, Faul JD, Fernandez-Rhodes L, Fohner AE, Franco OH, Galesloot TE, Gordon SD, Grarup N, Hartman CA, Heiss G, Hui J, Illig T, Jago R, James A, Joshi PK, Jung T, Kähönen M, Kilpeläinen TO, Koh WP, Kolcic I, Kraft PP, Kuusisto J, Launer LJ, Li A, Linneberg A, Luan J, Vidal PM, Medland SE, Milaneschi Y, Moscati A, Musk B, Nelson CP, Nolte IM, Pedersen NL, Peters A, Peyser PA, Power C, Raitakari OT, Reedik M, Reiner AP, Ridker PM, Rudan I, Ryan K, Sarzynski MA, Scott LJ, Scott RA, Sidney S, Siggeirsdottir K, Smith AV, Smith JA, Sonestedt E, Strøm M, Tai ES, Teo KK, Thorand B, Tönjes A, Tremblay A, Uitterlinden AG, Vangipurapu J, van Schoor N, Völker U, Willemsen G, Williams K, Wong Q, Xu H, Young KL, Yuan JM, Zillikens MC, Zonderman AB, Ameur A, Bandinelli S, Bis JC, Boehnke M, Bouchard C, Chasman DI, Smith GD, de Geus EJC, Deldicque L, Dörr M, Evans MK, Ferrucci L, Fornage M, Fox C, Garland T, Gudnason V, Gyllensten U, Hansen T, Hayward C, Horta BL, Hyppönen E, Jarvelin MR, Johnson WC, Kardia SLR, Kiemeney LA, Laakso M, Langenberg C, Lehtimäki T, Marchand LL, Lifelines Cohort Study, Magnusson PKE, Martin NG, Melbye M, Metspalu A, Meyre D, North KE, Ohlsson C, Oldehinkel AJ, Orho-Melander M, Pare G, Park T, Pedersen O, Penninx BWJH, Pers TH, Polasek O, Prokopenko I, Rotimi CN, Samani NJ, Sim X, Snieder H, Sørensen TIA, Spector TD, Timpson NJ, van Dam RM, van der Velde N, van Duijn CM, Vollenweider P, Völzke H, Voortman T, Waeber G, Wareham NJ, Weir DR, Wichmann HE, Wilson JF, Hevener AL, Krook A, Zierath JR, Thomis MAI, Loos RJF, Hoed MD. PMID: 36071172; PMCID: PMC9470530.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    8. Genetic variation of putative myokine signaling is dominated by biological sex and sex hormones. Elife. 2022 04 13; 11. Velez LM, Van C, Moore T, Zhou Z, Johnson C, Hevener AL, Seldin MM. PMID: 35416774; PMCID: PMC9094747.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    9. ABCB10 exports mitochondrial biliverdin, driving metabolic maladaptation in obesity. Sci Transl Med. 2021 05 19; 13(594). Shum M, Shintre CA, Althoff T, Gutierrez V, Segawa M, Saxberg AD, Martinez M, Adamson R, Young MR, Faust B, Gharakhanian R, Su S, Chella Krishnan K, Mahdaviani K, Veliova M, Wolf DM, Ngo J, Nocito L, Stiles L, Abramson J, Lusis AJ, Hevener AL, Zoghbi ME, Carpenter EP, Liesa M. PMID: 34011630; PMCID: PMC8300486.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    10. A pro-diabetogenic mtDNA polymorphism in the mitochondrial-derived peptide, MOTS-c. Aging (Albany NY). 2021 01 19; 13(2):1692-1717. Zempo H, Kim SJ, Fuku N, Nishida Y, Higaki Y, Wan J, Yen K, Miller B, Vicinanza R, Miyamoto-Mikami E, Kumagai H, Naito H, Xiao J, Mehta HH, Lee C, Hara M, Patel YM, Setiawan VW, Moore TM, Hevener AL, Sutoh Y, Shimizu A, Kojima K, Kinoshita K, Arai Y, Hirose N, Maeda S, Tanaka K, Cohen P. PMID: 33468709; PMCID: PMC7880332.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    11. Age-induced mitochondrial DNA point mutations are inadequate to alter metabolic homeostasis in response to nutrient challenge. Aging Cell. 2020 11; 19(11):e13166. Moore TM, Zhou Z, Strumwasser AR, Cohn W, Lin AJ, Cory K, Whitney K, Ho T, Ho T, Lee JL, Rucker DH, Hoang AN, Widjaja K, Abrishami AD, Charugundla S, Stiles L, Whitelegge JP, Turcotte LP, Wanagat J, Hevener AL. PMID: 33049094; PMCID: PMC7681042.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    12. ERα in the Control of Mitochondrial Function and Metabolic Health. Trends Mol Med. 2021 01; 27(1):31-46. Hevener AL, Ribas V, Moore TM, Zhou Z. PMID: 33020031.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    13. Estrogen receptor α controls metabolism in white and brown adipocytes by regulating Polg1 and mitochondrial remodeling. Sci Transl Med. 2020 08 05; 12(555). Zhou Z, Moore TM, Drew BG, Ribas V, Wanagat J, Civelek M, Segawa M, Wolf DM, Norheim F, Seldin MM, Strumwasser AR, Whitney KA, Lester E, Reddish BR, Vergnes L, Reue K, Rajbhandari P, Tontonoz P, Lee J, Mahata SK, Hewitt SC, Shirihai O, Gastonbury C, Small KS, Laakso M, Jensen J, Lee S, Drevon CA, Korach KS, Lusis AJ, Hevener AL. PMID: 32759275; PMCID: PMC8212422.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    14. The Impact of Skeletal Muscle ERα on Mitochondrial Function and Metabolic Health. Endocrinology. 2020 02 01; 161(2). Hevener AL, Ribas V, Moore TM, Zhou Z. PMID: 32053721; PMCID: PMC7017798.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    15. The impact of exercise on mitochondrial dynamics and the role of Drp1 in exercise performance and training adaptations in skeletal muscle. Mol Metab. 2019 03; 21:51-67. Moore TM, Zhou Z, Cohn W, Norheim F, Lin AJ, Kalajian N, Strumwasser AR, Cory K, Whitney K, Ho T, Ho T, Lee JL, Rucker DH, Shirihai O, van der Bliek AM, Whitelegge JP, Seldin MM, Lusis AJ, Lee S, Drevon CA, Mahata SK, Turcotte LP, Hevener AL. PMID: 30591411; PMCID: PMC6407367.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    16. The E3 ligase MARCH5 is a PPARγ target gene that regulates mitochondria and metabolism in adipocytes. Am J Physiol Endocrinol Metab. 2019 02 01; 316(2):E293-E304. Bond ST, Moody SC, Liu Y, Civelek M, Villanueva CJ, Gregorevic P, Kingwell BA, Hevener AL, Lusis AJ, Henstridge DC, Calkin AC, Drew BG. PMID: 30512991; PMCID: PMC6397360.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    17. New mitochondrial DNA synthesis enables NLRP3 inflammasome activation. Nature. 2018 08; 560(7717):198-203. Zhong Z, Liang S, Sanchez-Lopez E, He F, Shalapour S, Lin XJ, Wong J, Ding S, Seki E, Schnabl B, Hevener AL, Greenberg HB, Kisseleva T, Karin M. PMID: 30046112; PMCID: PMC6329306.
      View in: PubMed   Mentions: 440     Fields:    Translation:AnimalsCells
    18. The impact of ERα action on muscle metabolism and insulin sensitivity - Strong enough for a man, made for a woman. Mol Metab. 2018 09; 15:20-34. Hevener AL, Zhou Z, Moore TM, Drew BG, Ribas V. PMID: 30005878; PMCID: PMC6066787.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    19. Genetic, dietary, and sex-specific regulation of hepatic ceramides and the relationship between hepatic ceramides and IR. J Lipid Res. 2018 07; 59(7):1164-1174. Norheim F, Bjellaas T, Hui ST, Chella Krishnan K, Lee J, Gupta S, Pan C, Hasin-Brumshtein Y, Parks BW, Li DY, Bui HH, Mosier M, Wu Y, Huertas-Vazquez A, Hazen SL, Gundersen TE, Mehrabian M, Tang WHW, Hevener AL, Drevon CA, Lusis AJ. PMID: 29739864; PMCID: PMC6027922.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    20. Estrogen receptor α protects pancreatic β-cells from apoptosis by preserving mitochondrial function and suppressing endoplasmic reticulum stress. J Biol Chem. 2018 03 30; 293(13):4735-4751. Zhou Z, Ribas V, Rajbhandari P, Drew BG, Moore TM, Fluitt AH, Reddish BR, Whitney KA, Georgia S, Vergnes L, Reue K, Liesa M, Shirihai O, van der Bliek AM, Chi NW, Mahata SK, Tiano JP, Hewitt SC, Tontonoz P, Korach KS, Mauvais-Jarvis F, Hevener AL. PMID: 29378845; PMCID: PMC5880140.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    21. Digital PCR Quantitation of Muscle Mitochondrial DNA: Age, Fiber Type, and Mutation-Induced Changes. J Gerontol A Biol Sci Med Sci. 2017 Oct 01; 72(10):1327-1333. Herbst A, Widjaja K, Nguy B, Lushaj EB, Moore TM, Hevener AL, McKenzie D, Aiken JM, Wanagat J. PMID: 28460005; PMCID: PMC5861869.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    22. Relationships of sex hormone levels with leukocyte telomere length in Black, Hispanic, and Asian/Pacific Islander postmenopausal women. J Diabetes. 2018 Jun; 10(6):502-511. Song Y, Cho M, Brennan KM, Chen BH, Song Y, Manson JE, Hevener AL, You NY, Butch AW, Liu S. PMID: 28609023; PMCID: PMC6499547.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    23. Sex Hormones and Cardiometabolic Health: Role of Estrogen and Estrogen Receptors. Endocrinology. 2017 05 01; 158(5):1095-1105. Clegg D, Hevener AL, Moreau KL, Morselli E, Criollo A, Van Pelt RE, Vieira-Potter VJ. PMID: 28323912; PMCID: PMC6283431.
      View in: PubMed   Mentions: 38     Fields:    
    24. The Role of Skeletal Muscle Estrogen Receptors in Metabolic Homeostasis and Insulin Sensitivity. Adv Exp Med Biol. 2017; 1043:257-284. Hevener AL, Zhou Z, Drew BG, Ribas V. PMID: 29224099.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    25. Maternal obesity reduces oxidative capacity in fetal skeletal muscle of Japanese macaques. JCI Insight. 2016 Oct 06; 1(16):e86612. McCurdy CE, Schenk S, Hetrick B, Houck J, Drew BG, Kaye S, Lashbrook M, Bergman BC, Takahashi DL, Dean TA, Nemkov T, Gertsman I, Hansen KC, Philp A, Hevener AL, Chicco AJ, Aagaard KM, Grove KL, Friedman JE. PMID: 27734025; PMCID: PMC5053156.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    26. Mitochondrial quality control in insulin resistance and diabetes. Curr Opin Genet Dev. 2016 06; 38:118-126. Wanagat J, Hevener AL. PMID: 27318536; PMCID: PMC5067242.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    27. Skeletal muscle action of estrogen receptor α is critical for the maintenance of mitochondrial function and metabolic homeostasis in females. Sci Transl Med. 2016 Apr 13; 8(334):334ra54. Ribas V, Drew BG, Zhou Z, Phun J, Kalajian NY, Soleymani T, Daraei P, Widjaja K, Wanagat J, de Aguiar Vallim TQ, Fluitt AH, Bensinger S, Le T, Radu C, Whitelegge JP, Beaven SW, Tontonoz P, Lusis AJ, Parks BW, Vergnes L, Reue K, Singh H, Bopassa JC, Toro L, Stefani E, Watt MJ, Schenk S, Akerstrom T, Kelly M, Pedersen BK, Hewitt SC, Korach KS, Hevener AL. PMID: 27075628; PMCID: PMC4934679.
      View in: PubMed   Mentions: 107     Fields:    Translation:HumansAnimalsCells
    28. Failure to up-regulate transcription of genes necessary for muscle adaptation underlies limb girdle muscular dystrophy 2A (calpainopathy). Hum Mol Genet. 2016 06 01; 25(11):2194-2207. Kramerova I, Ermolova N, Eskin A, Hevener A, Quehenberger O, Armando AM, Haller R, Romain N, Nelson SF, Spencer MJ. PMID: 27005420; PMCID: PMC5081050.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    29. Women in Metabolism: Part 3. Cell Metab. 2015 Dec 01; 22(6):949-53. Ashcroft F, Pearce E, Partridge L, Suomalainen A, Brunet A, Schulze A, Tseng YH, Sethi JK, Reue K, Kingwell B, McNally E, Cnop M, Hevener AL, Diano S. PMID: 26636490.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    30. Calcineurin Links Mitochondrial Elongation with Energy Metabolism. Cell Metab. 2015 Nov 03; 22(5):838-50. Pfluger PT, Kabra DG, Aichler M, Schriever SC, Pfuhlmann K, García VC, Lehti M, Weber J, Kutschke M, Rozman J, Elrod JW, Hevener AL, Feuchtinger A, Hrabe de Angelis M, Walch A, Rollmann SM, Aronow BJ, Müller TD, Perez-Tilve D, Jastroch M, De Luca M, Molkentin JD, Tschöp MH. PMID: 26411342.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    31. Strength fitness and body weight status on markers of cardiometabolic health. Med Sci Sports Exerc. 2015 Jun; 47(6):1211-8. Roberts CK, Lee MM, Katiraie M, Krell SL, Angadi SS, Chronley MK, Oh CS, Ribas V, Harris RA, Hevener AL, Croymans DM. PMID: 25251047; PMCID: PMC5866050.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    32. Impaired estrogen receptor action in the pathogenesis of the metabolic syndrome. Mol Cell Endocrinol. 2015 Dec 15; 418 Pt 3:306-21. Hevener AL, Clegg DJ, Mauvais-Jarvis F. PMID: 26033249; PMCID: PMC5965692.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimals
    33. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab. 2015 Mar 03; 21(3):443-54. Lee C, Zeng J, Drew BG, Sallam T, Martin-Montalvo A, Wan J, Kim SJ, Mehta H, Hevener AL, de Cabo R, Cohen P. PMID: 25738459; PMCID: PMC4350682.
      View in: PubMed   Mentions: 256     Fields:    Translation:HumansAnimalsCells
    34. Genetic architecture of insulin resistance in the mouse. Cell Metab. 2015 Feb 03; 21(2):334-347. Parks BW, Sallam T, Mehrabian M, Psychogios N, Hui ST, Norheim F, Castellani LW, Rau CD, Pan C, Phun J, Zhou Z, Yang WP, Neuhaus I, Gargalovic PS, Kirchgessner TG, Graham M, Lee R, Tontonoz P, Gerszten RE, Hevener AL, Lusis AJ. PMID: 25651185; PMCID: PMC4349439.
      View in: PubMed   Mentions: 121     Fields:    Translation:Animals
    35. Birthweight, mediating biomarkers and the development of type 2 diabetes later in life: a prospective study of multi-ethnic women. Diabetologia. 2015 Jun; 58(6):1220-30. Song Y, Huang YT, Song Y, Hevener AL, Ryckman KK, Qi L, LeBlanc ES, Kazlauskaite R, Brennan KM, Liu S. PMID: 25567102; PMCID: PMC5947951.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    36. Estrogen receptor (ER)α-regulated lipocalin 2 expression in adipose tissue links obesity with breast cancer progression. J Biol Chem. 2015 Feb 27; 290(9):5566-81. Drew BG, Hamidi H, Zhou Z, Villanueva CJ, Krum SA, Calkin AC, Parks BW, Ribas V, Kalajian NY, Phun J, Daraei P, Christofk HR, Hewitt SC, Korach KS, Tontonoz P, Lusis AJ, Slamon DJ, Hurvitz SA, Hevener AL. PMID: 25468909; PMCID: PMC4342471.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    37. Activating HSP72 in rodent skeletal muscle increases mitochondrial number and oxidative capacity and decreases insulin resistance. Diabetes. 2014 Jun; 63(6):1881-94. Henstridge DC, Bruce CR, Drew BG, Tory K, Kolonics A, Estevez E, Chung J, Watson N, Gardner T, Lee-Young RS, Connor T, Watt MJ, Carpenter K, Hargreaves M, McGee SL, Hevener AL, Febbraio MA. PMID: 24430435; PMCID: PMC4030108.
      View in: PubMed   Mentions: 93     Fields:    Translation:AnimalsCells
    38. Tissue-selective estrogen complexes with bazedoxifene prevent metabolic dysfunction in female mice. Mol Metab. 2014 Apr; 3(2):177-90. Kim JH, Meyers MS, Khuder SS, Abdallah SL, Muturi HT, Russo L, Tate CR, Hevener AL, Najjar SM, Leloup C, Mauvais-Jarvis F. PMID: 24634829; PMCID: PMC3953695.
      View in: PubMed   Mentions: 48     Fields:    
    39. HSP72 is a mitochondrial stress sensor critical for Parkin action, oxidative metabolism, and insulin sensitivity in skeletal muscle. Diabetes. 2014 May; 63(5):1488-505. Drew BG, Ribas V, Le JA, Henstridge DC, Phun J, Zhou Z, Soleymani T, Daraei P, Sitz D, Vergnes L, Wanagat J, Reue K, Febbraio MA, Hevener AL. PMID: 24379352; PMCID: PMC3994950.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    40. Reciprocal regulation of hepatic and adipose lipogenesis by liver X receptors in obesity and insulin resistance. Cell Metab. 2013 Jul 02; 18(1):106-17. Beaven SW, Matveyenko A, Wroblewski K, Chao L, Wilpitz D, Hsu TW, Lentz J, Drew B, Hevener AL, Tontonoz P. PMID: 23823481; PMCID: PMC4089509.
      View in: PubMed   Mentions: 78     Fields:    Translation:AnimalsCells
    41. ERα regulates lipid metabolism in bone through ATGL and perilipin. J Cell Biochem. 2013 Jun; 114(6):1306-14. Wend K, Wend P, Drew BG, Hevener AL, Miranda-Carboni GA, Krum SA. PMID: 23296636; PMCID: PMC5879770.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    42. Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARγ specifies lipid storage versus thermogenic gene programs. Cell Metab. 2013 Mar 05; 17(3):423-35. Villanueva CJ, Vergnes L, Wang J, Drew BG, Hong C, Tu Y, Hu Y, Peng X, Xu F, Saez E, Wroblewski K, Hevener AL, Reue K, Fong LG, Young SG, Tontonoz P. PMID: 23473036; PMCID: PMC3626567.
      View in: PubMed   Mentions: 88     Fields:    Translation:AnimalsCells
    43. The role of estrogens in control of energy balance and glucose homeostasis. Endocr Rev. 2013 Jun; 34(3):309-38. Mauvais-Jarvis F, Clegg DJ, Hevener AL. PMID: 23460719; PMCID: PMC3660717.
      View in: PubMed   Mentions: 491     Fields:    Translation:HumansAnimalsCells
    44. Metabolic syndrome and insulin resistance: underlying causes and modification by exercise training. Compr Physiol. 2013 Jan; 3(1):1-58. Roberts CK, Hevener AL, Barnard RJ. PMID: 23720280; PMCID: PMC4129661.
      View in: PubMed   Mentions: 247     Fields:    Translation:HumansAnimals
    45. Skeletal muscle Nur77 expression enhances oxidative metabolism and substrate utilization. J Lipid Res. 2012 Dec; 53(12):2610-9. Chao LC, Wroblewski K, Ilkayeva OR, Stevens RD, Bain J, Meyer GA, Schenk S, Martinez L, Vergnes L, Narkar VA, Drew BG, Hong C, Boyadjian R, Hevener AL, Evans RM, Reue K, Spencer MJ, Newgard CB, Tontonoz P. PMID: 23028113; PMCID: PMC3494265.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    46. Membrane-lipid therapy in operation: the HSP co-inducer BGP-15 activates stress signal transduction pathways by remodeling plasma membrane rafts. PLoS One. 2011; 6(12):e28818. Gombos I, Crul T, Piotto S, Güngör B, Török Z, Balogh G, Péter M, Slotte JP, Campana F, Pilbat AM, Hunya A, Tóth N, Literati-Nagy Z, Vígh L, Glatz A, Brameshuber M, Schütz GJ, Hevener A, Febbraio MA, Horváth I, Vígh L. PMID: 22174906; PMCID: PMC3236211.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    47. Myeloid-specific estrogen receptor alpha deficiency impairs metabolic homeostasis and accelerates atherosclerotic lesion development. Proc Natl Acad Sci U S A. 2011 Sep 27; 108(39):16457-62. Ribas V, Drew BG, Le JA, Soleymani T, Daraei P, Sitz D, Mohammad L, Henstridge DC, Febbraio MA, Hewitt SC, Korach KS, Bensinger SJ, Hevener AL. PMID: 21900603; PMCID: PMC3182726.
      View in: PubMed   Mentions: 98     Fields:    Translation:AnimalsCells
    48. Hepatic acyl-CoA:diacylglcyerol acyltransferase (DGAT) overexpression, diacylglycerol, and insulin sensitivity. Proc Natl Acad Sci U S A. 2011 Aug 23; 108(34):E523; author reply E524. Monetti M, Levin MC, Watt MJ, Hubbard BK, Newgard C, Farese RV, Hevener AL, Farese RV. PMID: 21807991; PMCID: PMC3161537.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    49. TLE3 is a dual-function transcriptional coregulator of adipogenesis. Cell Metab. 2011 Apr 06; 13(4):413-427. Villanueva CJ, Waki H, Godio C, Nielsen R, Chou WL, Vargas L, Wroblewski K, Schmedt C, Chao LC, Boyadjian R, Mandrup S, Hevener A, Saez E, Tontonoz P. PMID: 21459326; PMCID: PMC3089971.
      View in: PubMed   Mentions: 87     Fields:    Translation:AnimalsCells
    50. Liver-specific suppressor of cytokine signaling-3 deletion in mice enhances hepatic insulin sensitivity and lipogenesis resulting in fatty liver and obesity. Hepatology. 2010 Nov; 52(5):1632-42. Sachithanandan N, Fam BC, Fynch S, Dzamko N, Watt MJ, Wormald S, Honeyman J, Galic S, Proietto J, Andrikopoulos S, Hevener AL, Kay TW, Steinberg GR. PMID: 20799351.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    51. Evidence of a role for insulin-like growth factor binding protein (IGFBP)-3 in metabolic regulation. Endocrinology. 2010 Dec; 151(12):5741-50. Yamada PM, Mehta HH, Hwang D, Roos KP, Hevener AL, Lee KW. PMID: 20926583; PMCID: PMC2999488.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    52. The 2009 stock conference report: inflammation, obesity and metabolic disease. Obes Rev. 2010 Sep; 11(9):635-44. Hevener AL, Febbraio MA, Stock Conference Working Group. PMID: 20002885.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    53. Sarcopenia exacerbates obesity-associated insulin resistance and dysglycemia: findings from the National Health and Nutrition Examination Survey III. PLoS One. 2010 May 26; 5(5):e10805. Srikanthan P, Hevener AL, Karlamangla AS. PMID: 22421977; PMCID: PMC3279294.
      View in: PubMed   Mentions: 236     Fields:    Translation:Humans
    54. Impaired oxidative metabolism and inflammation are associated with insulin resistance in ERalpha-deficient mice. Am J Physiol Endocrinol Metab. 2010 Feb; 298(2):E304-19. Ribas V, Nguyen MT, Henstridge DC, Nguyen AK, Beaven SW, Watt MJ, Hevener AL. PMID: 19920214; PMCID: PMC2822483.
      View in: PubMed   Mentions: 162     Fields:    Translation:AnimalsCells
    55. AMPK beta1 deletion reduces appetite, preventing obesity and hepatic insulin resistance. J Biol Chem. 2010 Jan 01; 285(1):115-22. Dzamko N, van Denderen BJ, Hevener AL, Jørgensen SB, Honeyman J, Galic S, Chen ZP, Watt MJ, Campbell DJ, Steinberg GR, Kemp BE. PMID: 19892703; PMCID: PMC2804155.
      View in: PubMed   Mentions: 84     Fields:    Translation:AnimalsCells
    56. Insulin resistance and altered systemic glucose metabolism in mice lacking Nur77. Diabetes. 2009 Dec; 58(12):2788-96. Chao LC, Wroblewski K, Zhang Z, Pei L, Vergnes L, Ilkayeva OR, Ding SY, Reue K, Watt MJ, Newgard CB, Pilch PF, Hevener AL, Tontonoz P. PMID: 19741162; PMCID: PMC2780886.
      View in: PubMed   Mentions: 79     Fields:    Translation:AnimalsCells
    57. Hypermetabolism, hyperphagia, and reduced adiposity in tankyrase-deficient mice. Diabetes. 2009 Nov; 58(11):2476-85. Yeh TY, Beiswenger KK, Li P, Bolin KE, Lee RM, Tsao TS, Murphy AN, Hevener AL, Chi NW. PMID: 19651815; PMCID: PMC2768175.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    58. Pigment epithelium-derived factor contributes to insulin resistance in obesity. Cell Metab. 2009 Jul; 10(1):40-7. Crowe S, Wu LE, Economou C, Turpin SM, Matzaris M, Hoehn KL, Hevener AL, James DE, Duh EJ, Watt MJ. PMID: 19583952.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    59. Examination of 'lipotoxicity' in skeletal muscle of high-fat fed and ob/ob mice. J Physiol. 2009 Apr 01; 587(Pt 7):1593-605. Turpin SM, Ryall JG, Southgate R, Darby I, Hevener AL, Febbraio MA, Kemp BE, Lynch GS, Watt MJ. PMID: 19204053; PMCID: PMC2678228.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    60. HSP72 protects against obesity-induced insulin resistance. Proc Natl Acad Sci U S A. 2008 Feb 05; 105(5):1739-44. Chung J, Nguyen AK, Henstridge DC, Holmes AG, Chan MH, Mesa JL, Lancaster GI, Southgate RJ, Bruce CR, Duffy SJ, Horvath I, Mestril R, Watt MJ, Hooper PL, Kingwell BA, Vigh L, Hevener A, Febbraio MA. PMID: 18223156; PMCID: PMC2234214.
      View in: PubMed   Mentions: 236     Fields:    Translation:HumansAnimalsCells
    61. Fluxing the mitochondria to insulin resistance. Cell Metab. 2008 Jan; 7(1):5-6. Watt MJ, Hevener AL. PMID: 18177719.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    62. Macrophage peroxisome proliferator activated receptor gamma as a therapeutic target to combat Type 2 diabetes. Expert Opin Ther Targets. 2007 Nov; 11(11):1503-20. Pascual G, Ricote M, Hevener AL. PMID: 18028013.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    63. Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver. Cell Metab. 2007 Jul; 6(1):69-78. Monetti M, Levin MC, Watt MJ, Sajan MP, Marmor S, Hubbard BK, Stevens RD, Bain JR, Newgard CB, Farese RV, Hevener AL, Farese RV. PMID: 17618857.
      View in: PubMed   Mentions: 245     Fields:    Translation:HumansAnimalsCells
    64. Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones. J Clin Invest. 2007 Jun; 117(6):1658-69. Hevener AL, Olefsky JM, Reichart D, Nguyen MT, Bandyopadyhay G, Leung HY, Watt MJ, Benner C, Febbraio MA, Nguyen AK, Folian B, Subramaniam S, Gonzalez FJ, Glass CK, Ricote M. PMID: 17525798; PMCID: PMC1868788.
      View in: PubMed   Mentions: 245     Fields:    Translation:AnimalsCells
    65. Thiazolidinediones enhance skeletal muscle triacylglycerol synthesis while protecting against fatty acid-induced inflammation and insulin resistance. Am J Physiol Endocrinol Metab. 2007 Feb; 292(2):E485-93. Todd MK, Watt MJ, Le J, Hevener AL, Turcotte LP. PMID: 17003244.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    66. PPARdelta regulates glucose metabolism and insulin sensitivity. Proc Natl Acad Sci U S A. 2006 Feb 28; 103(9):3444-9. Lee CH, Olson P, Hevener A, Mehl I, Chong LW, Olefsky JM, Gonzalez FJ, Ham J, Kang H, Peters JM, Evans RM. PMID: 16492734; PMCID: PMC1413918.
      View in: PubMed   Mentions: 204     Fields:    Translation:AnimalsCells
    67. Ciliary neurotrophic factor prevents acute lipid-induced insulin resistance by attenuating ceramide accumulation and phosphorylation of c-Jun N-terminal kinase in peripheral tissues. Endocrinology. 2006 May; 147(5):2077-85. Watt MJ, Hevener A, Lancaster GI, Febbraio MA. PMID: 16396984.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    68. Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin action. Nat Med. 2005 May; 11(5):567-71. Bard-Chapeau EA, Hevener AL, Long S, Zhang EE, Olefsky JM, Feng GS. PMID: 15821749.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    69. IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med. 2005 Feb; 11(2):191-8. Arkan MC, Hevener AL, Greten FR, Maeda S, Li ZW, Long JM, Wynshaw-Boris A, Poli G, Olefsky J, Karin M. PMID: 15685170.
      View in: PubMed   Mentions: 773     Fields:    Translation:AnimalsCells
    70. Adiposity, dyslipidemia, and insulin resistance in mice with targeted deletion of phospholipid scramblase 3 (PLSCR3). Proc Natl Acad Sci U S A. 2004 Sep 07; 101(36):13296-301. Wiedmer T, Zhao J, Li L, Zhou Q, Hevener A, Olefsky JM, Curtiss LK, Sims PJ. PMID: 15328404; PMCID: PMC516563.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    71. Effect of endurance training and fasting on renal gluconeogenic enzymes in the rat. Int J Sport Nutr Exerc Metab. 2004 Jun; 14(3):323-32. Sumida KD, Garrett JH, McJilton WT, Hevener AL, Donovan CM. PMID: 15256692.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    72. Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):15712-7. He W, Barak Y, Hevener A, Olson P, Liao D, Le J, Nelson M, Ong E, Olefsky JM, Evans RM. PMID: 14660788; PMCID: PMC307633.
      View in: PubMed   Mentions: 449     Fields:    Translation:AnimalsCells
    73. Muscle-specific Pparg deletion causes insulin resistance. Nat Med. 2003 Dec; 9(12):1491-7. Hevener AL, He W, Barak Y, Le J, Bandyopadhyay G, Olson P, Wilkes J, Evans RM, Olefsky J. PMID: 14625542.
      View in: PubMed   Mentions: 203     Fields:    Translation:AnimalsCells
    74. Chronic endothelin-1 treatment leads to insulin resistance in vivo. Diabetes. 2003 Aug; 52(8):1904-9. Wilkes JJ, Hevener A, Olefsky J. PMID: 12882904.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    75. The effect of thiazolidinediones on plasma adiponectin levels in normal, obese, and type 2 diabetic subjects. Diabetes. 2002 Oct; 51(10):2968-74. Yu JG, Javorschi S, Hevener AL, Kruszynska YT, Norman RA, Sinha M, Olefsky JM. PMID: 12351435.
      View in: PubMed   Mentions: 195     Fields:    Translation:HumansAnimalsCTClinical Trials
    76. Female rats do not exhibit free fatty acid-induced insulin resistance. Diabetes. 2002 Jun; 51(6):1907-12. Hevener A, Reichart D, Janez A, Olefsky J. PMID: 12031980.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    77. Synthesis of an organoinsulin molecule that can be activated by antibody catalysis. Proc Natl Acad Sci U S A. 2001 Nov 20; 98(24):13514-8. Worrall DS, McDunn JE, List B, Reichart D, Hevener A, Gustafson T, Barbas CF, Lerner RA, Olefsky JM. PMID: 11707596; PMCID: PMC61072.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    78. Hypoglycemic detection does not occur in the hepatic artery or liver: findings consistent with a portal vein glucosensor locus. Diabetes. 2001 Feb; 50(2):399-403. Hevener AL, Bergman RN, Donovan CM. PMID: 11272153.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    79. Exercise and thiazolidinedione therapy normalize insulin action in the obese Zucker fatty rat. Diabetes. 2000 Dec; 49(12):2154-9. Hevener AL, Reichart D, Olefsky J. PMID: 11118020.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    80. Portal vein afferents are critical for the sympathoadrenal response to hypoglycemia. Diabetes. 2000 Jan; 49(1):8-12. Hevener AL, Bergman RN, Donovan CM. PMID: 10615943.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    81. Novel glucosensor for hypoglycemic detection localized to the portal vein. Diabetes. 1997 Sep; 46(9):1521-5. Hevener AL, Bergman RN, Donovan CM. PMID: 9287058.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
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