Aldons J Lusis

Title(s)Professor, Medicine
SchoolMedicine
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    Other Positions
    Title(s)Professor, Human Genetics

    Title(s)Professor, MIMG


    Collapse Research 
    Collapse Research Activities and Funding
    Systems-based approaches for investigating tissue communication during exercise
    NIH U01AG070959Sep 30, 2020 - May 31, 2023
    Role: Co-Principal Investigator
    Establishing mechanistic links between the gut microbiome and atherosclerosis
    NIH R01HL148577Apr 1, 2020 - Mar 31, 2024
    Role: Co-Principal Investigator
    Systems genetics approach to inflammatory mechanisms in atherosclerosis
    NIH R01HL147883Jul 12, 2019 - May 31, 2023
    Role: Principal Investigator
    Systems genetics dissection of non-alcoholic steatohepatitis
    NIH R01DK117850Jul 1, 2019 - Jun 30, 2023
    Role: Principal Investigator
    Gut microbiota and metabolite interactions in atherosclerosis
    NIH R01HL144651Jan 15, 2019 - Oct 31, 2022
    Role: Principal Investigator
    Pharmacogenomics of Statin Therapy
    NIH P50GM115318Sep 7, 2015 - Aug 31, 2021
    Role: Co-Principal Investigator
    Systems Genetics Approach to Atherosclerosis
    NIH R01HL126753Mar 9, 2015 - Jul 1, 2015
    Role: Principal Investigator
    A Systems Approach to Dissect Genetic Basis of Heart Failure
    NIH R01HL123295Apr 1, 2014 - Mar 31, 2018
    Role: Co-Principal Investigator
    Systems Approach to Unraveling the Genetic Basis of Heart Failure
    NIH R01HL114437Sep 4, 2013 - May 31, 2017
    Role: Co-Principal Investigator
    Systems Genetics of Type 1 Diabetes Complications
    NIH DP3DK094311Sep 30, 2011 - Jun 30, 2016
    Role: Principal Investigator
    A Systems Approach to Uncover Novel Genes and Networks in Heart Failure
    NIH R21HL110667Aug 15, 2011 - Jul 31, 2013
    Role: Principal Investigator
    Dissection of HDL function using mouse models
    NIH R01HL094322Jul 15, 2009 - Apr 30, 2014
    Role: Principal Investigator
    Integrative genetic approaches to Atherosclerosis
    NIH R01HL095154Jul 15, 2009 - Jun 30, 2011
    Role: Principal Investigator
    Genetic Analysis of the Diabetes-Prone C57BLKS Strain
    NIH R01DK071673Aug 15, 2005 - Jun 30, 2010
    Role: Principal Investigator
    LIPOPROTEIN METABOLISM GENETIC CONTROL--MOUSE MODEL
    NIH R37HL042488Jul 1, 1989 - May 31, 2000
    Role: Principal Investigator
    LIPOPROTEIN METABOLISM GENETIC CONTROL--MOUSE MODEL
    NIH R01HL042488Jul 1, 1989 - May 30, 1999
    Role: Principal Investigator
    Molecular Genetic Approaches in Atherosclerosis Research
    NIH P01HL028481Jul 1, 1983 - Apr 30, 2021
    Role: Principal Investigator
    CONTROL OF GRANULOPOIESIS: MOLECULAR GENETIC APPROACH
    NIH R01AM027008Jan 1, 1981 - Dec 31, 1988
    Role: Principal Investigator
    CONTROL OF GRANULOPOIESIS: MOLECULAR GENETIC APPROACH
    NIH R01DK027008Jan 1, 1981 - Dec 31, 1988
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Effects of dietary iron deficiency or overload on bone: Dietary details matter. Bone. 2024 Apr 02; 117092. Baschant U, Fuqua BK, Ledesma-Colunga M, Vulpe CD, McLachlan S, Hofbauer LC, Lusis AJ, Rauner M. PMID: 38575048.
      View in: PubMed   Mentions:    Fields:    
    2. TRIM13 reduces cholesterol efflux and increases oxidized LDL uptake leading to foam cell formation and atherosclerosis. J Biol Chem. 2024 Mar 25; 107224. Govatati S, Kumar R, Boro M, Traylor JG, Orr AW, Lusis AJ, Rao GN. PMID: 38537695.
      View in: PubMed   Mentions:    Fields:    
    3. Relationships and Mendelian Randomization of Gut Microbe-Derived Metabolites with Metabolic Syndrome Traits in the METSIM Cohort. Metabolites. 2024 Mar 20; 14(3). Mirzaei S, DeVon HA, Cantor RM, Cupido AJ, Pan C, Ha SM, Silva LF, Hilser JR, Hartiala J, Allayee H, Rey FE, Laakso M, Lusis AJ. PMID: 38535334; PMCID: PMC10972019.
      View in: PubMed   Mentions:
    4. Systems genetics approach uncovers associations between host amylase locus, gut microbiome and metabolic traits in hyperlipidemic mice. bioRxiv. 2024 Mar 03. Zhang Q, Hutchison ER, Pan C, Warren MF, Keller MP, Attie AD, Lusis AJ, Rey FE. PMID: 38464150; PMCID: PMC10925268.
      View in: PubMed   Mentions:
    5. Genetics unravels protein-metabolite relationships. Trends Endocrinol Metab. 2024 03; 35(3):183-184. Hilser JR, Lusis AJ, Allayee H. PMID: 38302401; PMCID: PMC10939837.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Indole-3-Propionic Acid Protects Against Heart Failure With Preserved Ejection Fraction. Circ Res. 2024 02 16; 134(4):371-389. Wang YC, Koay YC, Pan C, Zhou Z, Tang W, Wilcox J, Li XS, Zagouras A, Marques F, Allayee H, Rey FE, Kaye DM, O'Sullivan JF, Hazen SL, Cao Y, Lusis AJ. PMID: 38264909; PMCID: PMC10923103.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    7. Effect of Genetic and Dietary Perturbation of Glycine Metabolism on Atherosclerosis in Humans and Mice. medRxiv. 2023 Dec 11. Biswas S, Hilser JR, Woodward NC, Wang Z, Gukasyan J, Nemet I, Schwartzman WS, Huang P, Han Y, Fouladian Z, Charugundla S, Spencer NJ, Pan C, Tang WHW, Lusis AJ, Hazen SL, Hartiala JA, Allayee H. PMID: 38168321; PMCID: PMC10760269.
      View in: PubMed   Mentions:
    8. Shared and distinct pathways and networks genetically linked to coronary artery disease between human and mouse. Elife. 2023 Dec 07; 12. Kurt Z, Cheng J, Barrere-Cain R, McQuillen CN, Saleem Z, Hsu N, Jiang N, Pan C, Franzén O, Koplev S, Wang S, Björkegren J, Lusis AJ, Blencowe M, Yang X. PMID: 38060277; PMCID: PMC10703441.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    9. Gene Regulatory Networks in Coronary Artery Disease. Curr Atheroscler Rep. 2023 Dec; 25(12):1013-1023. Cheng J, Cheng M, Lusis AJ, Yang X. PMID: 38008808.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Systems genetics approaches for understanding complex traits with relevance for human disease. Elife. 2023 11 14; 12. Allayee H, Farber CR, Seldin MM, Williams EG, James DE, Lusis AJ. PMID: 37962168; PMCID: PMC10645424.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    11. Shared and distinct pathways and networks genetically linked to coronary artery disease between human and mouse. bioRxiv. 2023 Sep 20. Kurt Z, Cheng J, McQuillen CN, Saleem Z, Hsu N, Jiang N, Barrere-Cain R, Pan C, Franzen O, Koplev S, Wang S, Bjorkegren J, Lusis AJ, Blencowe M, Yang X. PMID: 37333408; PMCID: PMC10274918.
      View in: PubMed   Mentions: 1  
    12. Role of Matrix Gla Protein in Transforming Growth Factor-β Signaling and Nonalcoholic Steatohepatitis in Mice. Cell Mol Gastroenterol Hepatol. 2023; 16(6):943-960. Hui ST, Gong L, Swichkow C, Blencowe M, Kaminska D, Diamante G, Pan C, Dalsania M, French SW, Magyar CE, Pajukanta P, Pihlajamäki J, Boström KI, Yang X, Lusis AJ. PMID: 37611662; PMCID: PMC10632746.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    13. Mammary duct luminal epithelium controls adipocyte thermogenic programme. Nature. 2023 Aug; 620(7972):192-199. Patel S, Sparman NZR, Arneson D, Alvarsson A, Santos LC, Duesman SJ, Centonze A, Hathaway E, Ahn IS, Diamante G, Cely I, Cho CH, Talari NK, Rajbhandari AK, Goedeke L, Wang P, Butte AJ, Blanpain C, Chella Krishnan K, Lusis AJ, Stanley SA, Yang X, Rajbhandari P. PMID: 37495690; PMCID: PMC10529063.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    14. Genetic architecture of heart mitochondrial proteome influencing cardiac hypertrophy. Elife. 2023 06 05; 12. Chella Krishnan K, El Hachem EJ, Keller MP, Patel SG, Carroll L, Vegas AD, Gerdes Gyuricza I, Light C, Cao Y, Pan C, Kaczor-Urbanowicz KE, Shravah V, Anum D, Pellegrini M, Lee CF, Seldin MM, Rosenthal NA, Churchill GA, Attie AD, Parker B, James DE, Lusis AJ. PMID: 37276142; PMCID: PMC10241513.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    15. Gut bacterial metabolism contributes to host global purine homeostasis. Cell Host Microbe. 2023 06 14; 31(6):1038-1053.e10. Kasahara K, Kerby RL, Zhang Q, Pradhan M, Mehrabian M, Lusis AJ, Bergström G, Bäckhed F, Rey FE. PMID: 37279756; PMCID: PMC10311284.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    16. Fructose induced KHK-C can increase ER stress independent of its effect on lipogenesis to drive liver disease in diet-induced and genetic models of NAFLD. Metabolism. 2023 08; 145:155591. Park SH, Helsley RN, Fadhul T, Willoughby JLS, Noetzli L, Tu HC, Solheim MH, Fujisaka S, Pan H, Dreyfuss JM, Bons J, Rose J, King CD, Schilling B, Lusis AJ, Pan C, Gupta M, Kulkarni RN, Fitzgerald K, Kern PA, Divanovic S, Kahn CR, Softic S. PMID: 37230214; PMCID: PMC10752375.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    17. Conserved multi-tissue transcriptomic adaptations to exercise training in humans and mice. Cell Rep. 2023 05 30; 42(5):112499. Moore TM, Lee S, Olsen T, Morselli M, Strumwasser AR, Lin AJ, Zhou Z, Abrishami A, Garcia SM, Bribiesca J, Cory K, Whitney K, Ho T, Ho T, Lee JL, Rucker DH, Nguyen CQA, Anand ATS, Yackly A, Mendoza LQ, Leyva BK, Aliman C, Artiga DJ, Meng Y, Charugundla S, Pan C, Jedian V, Seldin MM, Ahn IS, Diamante G, Blencowe M, Yang X, Mouisel E, Pellegrini M, Turcotte LP, Birkeland KI, Norheim F, Drevon CA, Lusis AJ, Hevener AL. PMID: 37178122.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    18. Author Correction: Genetic mapping of microbial and host traits reveals production of immunomodulatory lipids by Akkermansia muciniphila in the murine gut. Nat Microbiol. 2023 Apr; 8(4):745. Zhang Q, Linke V, Overmyer KA, Traeger LL, Kasahara K, Miller IJ, Manson DE, Polaske TJ, Kerby RL, Kemis JH, Trujillo EA, Reddy TR, Russell JD, Schueler KL, Stapleton DS, Rabaglia ME, Seldin M, Gatti DM, Keele GR, Pham DT, Gerdt JP, Vivas EI, Lusis AJ, Keller MP, Churchill GA, Blackwell HE, Broman KW, Attie AD, Coon JJ, Rey FE. PMID: 36973420; PMCID: PMC10066032.
      View in: PubMed   Mentions:    Fields:    
    19. Intestinal cell type-specific communication networks underlie homeostasis and response to Western diet. J Exp Med. 2023 05 01; 220(5). Wang YC, Cao Y, Pan C, Zhou Z, Yang L, Lusis AJ. PMID: 36880999; PMCID: PMC10038833.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    20. MBOAT7-driven lysophosphatidylinositol acylation in adipocytes contributes to systemic glucose homeostasis. J Lipid Res. 2023 04; 64(4):100349. Massey WJ, Varadharajan V, Banerjee R, Brown AL, Horak AJ, Hohe RC, Jung BM, Qiu Y, Chan ER, Pan C, Zhang R, Allende DS, Willard B, Cheng F, Lusis AJ, Brown JM. PMID: 36806709; PMCID: PMC10041558.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    21. Genetic mapping of microbial and host traits reveals production of immunomodulatory lipids by Akkermansia muciniphila in the murine gut. Nat Microbiol. 2023 03; 8(3):424-440. Zhang Q, Linke V, Overmyer KA, Traeger LL, Kasahara K, Miller IJ, Manson DE, Polaske TJ, Kerby RL, Kemis JH, Trujillo EA, Reddy TR, Russell JD, Schueler KL, Stapleton DS, Rabaglia ME, Seldin M, Gatti DM, Keele GR, Pham DT, Gerdt JP, Vivas EI, Lusis AJ, Keller MP, Churchill GA, Blackwell HE, Broman KW, Attie AD, Coon JJ, Rey FE. PMID: 36759753; PMCID: PMC9981464.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    22. Fructose Induced KHK-C Increases ER Stress and Modulates Hepatic Transcriptome to Drive Liver Disease in Diet-Induced and Genetic Models of NAFLD. bioRxiv. 2023 Jan 27. Park SH, Helsley RN, Fadhul T, Willoughby JLS, Noetzli L, Tu HC, Solheim MH, Fujisaka S, Pan H, Dreyfuss JM, Bons J, Rose J, King CD, Schilling B, Lusis AJ, Pan C, Gupta M, Kulkarni RN, Fitzgerald K, Kern PA, Divanovic S, Kahn CR, Softic S. PMID: 36747758; PMCID: PMC9900898.
      View in: PubMed   Mentions:
    23. Proteome-wide systems genetics identifies UFMylation as a regulator of skeletal muscle function. Elife. 2022 12 06; 11. Molendijk J, Blazev R, Mills RJ, Ng YK, Watt KI, Chau D, Gregorevic P, Crouch PJ, Hilton JBW, Lisowski L, Zhang P, Reue K, Lusis AJ, Hudson JE, James DE, Seldin MM, Parker BL. PMID: 36472367; PMCID: PMC9833826.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    24. Coagulation factor with potential for the treatment of heart failure. Clin Transl Med. 2022 Dec; 12(12):e1144. Cao Y, Lusis AJ. PMID: 36513961.
      View in: PubMed   Mentions:    Fields:    
    25. Parkin regulates adiposity by coordinating mitophagy with mitochondrial biogenesis in white adipocytes. Nat Commun. 2022 Nov 04; 13(1):6661. Moore TM, Cheng L, Wolf DM, Ngo J, Segawa M, Zhu X, Strumwasser AR, Cao Y, Clifford BL, Ma A, Scumpia P, Shirihai OS, Vallim TQA, Laakso M, Lusis AJ, Hevener AL, Zhou Z. PMID: 36333379; PMCID: PMC9636263.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    26. Liver-heart cross-talk mediated by coagulation factor XI protects against heart failure. Science. 2022 09 23; 377(6613):1399-1406. Cao Y, Wang Y, Zhou Z, Pan C, Jiang L, Zhou Z, Meng Y, Charugundla S, Li T, Allayee H, Seldin MM, Lusis AJ. PMID: 36137043; PMCID: PMC9639660.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    27. Identification of the Transcription Factor ATF3 as a Direct and Indirect Regulator of the LDLR. Metabolites. 2022 Sep 06; 12(9). Bauer S, Eigenmann J, Zhao Y, Fleig J, Hawe JS, Pan C, Bongiovanni D, Wengert S, Ma A, Lusis AJ, Kovacic JC, Björkegren JLM, Maegdefessel L, Schunkert H, von Scheidt M. PMID: 36144244; PMCID: PMC9504235.
      View in: PubMed   Mentions: 3  
    28. Altered branched-chain α-keto acid metabolism is a feature of NAFLD in individuals with severe obesity. JCI Insight. 2022 08 08; 7(15). Grenier-Larouche T, Coulter Kwee L, Deleye Y, Leon-Mimila P, Walejko JM, McGarrah RW, Marceau S, Trahan S, Racine C, Carpentier AC, Lusis AJ, Ilkayeva O, Vohl MC, Huertas-Vazquez A, Tchernof A, Shah SH, Newgard CB, White PJ. PMID: 35797133; PMCID: PMC9462486.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    29. Role of gut microbe-derived metabolites in cardiometabolic diseases: Systems based approach. Mol Metab. 2022 10; 64:101557. Cao Y, Aquino-Martinez R, Hutchison E, Allayee H, Lusis AJ, Rey FE. PMID: 35870705; PMCID: PMC9399267.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    30. Sex differences in heart mitochondria regulate diastolic dysfunction. Nat Commun. 2022 07 04; 13(1):3850. Cao Y, Vergnes L, Wang YC, Pan C, Chella Krishnan K, Moore TM, Rosa-Garrido M, Kimball TH, Zhou Z, Charugundla S, Rau CD, Seldin MM, Wang J, Wang Y, Vondriska TM, Reue K, Lusis AJ. PMID: 35787630; PMCID: PMC9253085.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    31. Oxy210, a Semi-Synthetic Oxysterol, Exerts Anti-Inflammatory Effects in Macrophages via Inhibition of Toll-like Receptor (TLR) 4 and TLR2 Signaling and Modulation of Macrophage Polarization. Int J Mol Sci. 2022 May 13; 23(10). Wang F, Stappenbeck F, Tang LY, Zhang YE, Hui ST, Lusis AJ, Parhami F. PMID: 35628290; PMCID: PMC9141227.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    32. Atherosclerosis: Recent developments. Cell. 2022 05 12; 185(10):1630-1645. Björkegren JLM, Lusis AJ. PMID: 35504280; PMCID: PMC9119695.
      View in: PubMed   Mentions: 140     Fields:    Translation:HumansCells
    33. Publisher Correction: Transcriptome-wide association study of coronary artery disease identifies novel susceptibility genes. Basic Res Cardiol. 2022 Apr 05; 117(1):19. Li L, Chen Z, von Scheidt M, Li S, Steiner A, Güldener U, Koplev S, Ma A, Hao K, Pan C, Lusis AJ, Pang S, Kessler T, Ermel R, Sukhavasi K, Ruusalepp A, Gagneur J, Erdmann J, Kovacic JC, Björkegren JLM, Schunkert H. PMID: 35381883; PMCID: PMC8983629.
      View in: PubMed   Mentions: 1     Fields:    
    34. Identification of DNA Damage Repair Enzyme Ascc2 as Causal for Heart Failure With Preserved Ejection Fraction. Circulation. 2022 04 05; 145(14):1102-1104. Cao Y, Pan C, Wang YC, Zhou Z, Jedian V, Meng Y, Campbell G, Guardino K, Li C, Wang J, Lusis AJ. PMID: 35377742; PMCID: PMC8988871.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    35. Transcriptome-wide association study of coronary artery disease identifies novel susceptibility genes. Basic Res Cardiol. 2022 02 17; 117(1):6. Li L, Chen Z, von Scheidt M, Li S, Steiner A, Güldener U, Koplev S, Ma A, Hao K, Pan C, Lusis AJ, Pang S, Kessler T, Ermel R, Sukhavasi K, Ruusalepp A, Gagneur J, Erdmann J, Kovacic JC, Björkegren JLM, Schunkert H. PMID: 35175464; PMCID: PMC8852935.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    36. Placental genomics mediates genetic associations with complex health traits and disease. Nat Commun. 2022 02 04; 13(1):706. Bhattacharya A, Freedman AN, Avula V, Harris R, Liu W, Pan C, Lusis AJ, Joseph RM, Smeester L, Hartwell HJ, Kuban KCK, Marsit CJ, Li Y, O'Shea TM, Fry RC, Santos HP. PMID: 35121757; PMCID: PMC8817049.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    37. Gut microbe-targeted choline trimethylamine lyase inhibition improves obesity via rewiring of host circadian rhythms. Elife. 2022 01 24; 11. Schugar RC, Gliniak CM, Osborn LJ, Massey W, Sangwan N, Horak A, Banerjee R, Orabi D, Helsley RN, Brown AL, Burrows A, Finney C, Fung KK, Allen FM, Ferguson D, Gromovsky AD, Neumann C, Cook K, McMillan A, Buffa JA, Anderson JT, Mehrabian M, Goudarzi M, Willard B, Mak TD, Armstrong AR, Swanson G, Keshavarzian A, Garcia-Garcia JC, Wang Z, Lusis AJ, Hazen SL, Brown JM. PMID: 35072627; PMCID: PMC8813054.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    38. Cardiomyocytes disrupt pyrimidine biosynthesis in nonmyocytes to regulate heart repair. J Clin Invest. 2022 01 18; 132(2). Li S, Yokota T, Wang P, Ten Hoeve J, Ma F, Le TM, Abt ER, Zhou Y, Wu R, Nanthavongdouangsy M, Rodriguez A, Wang Y, Lin YJ, Muranaka H, Sharpley M, Braddock DT, MacRae VE, Banerjee U, Chiou PY, Seldin M, Huang D, Teitell M, Gertsman I, Jung M, Bensinger SJ, Damoiseaux R, Faull K, Pellegrini M, Lusis AJ, Graeber TG, Radu CG, Deb A. PMID: 34813507; PMCID: PMC8759793.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    39. β3-Adrenergic receptor downregulation leads to adipocyte catecholamine resistance in obesity. J Clin Invest. 2022 01 18; 132(2). Valentine JM, Ahmadian M, Keinan O, Abu-Odeh M, Zhao P, Zhou X, Keller MP, Gao H, Yu RT, Liddle C, Downes M, Zhang J, Lusis AJ, Attie AD, Evans RM, Rydén M, Saltiel AR. PMID: 34847077; PMCID: PMC8759781.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    40. A mechanistic framework for cardiometabolic and coronary artery diseases. Nat Cardiovasc Res. 2022 Jan; 1(1):85-100. Koplev S, Seldin M, Sukhavasi K, Ermel R, Pang S, Zeng L, Bankier S, Di Narzo A, Cheng H, Meda V, Ma A, Talukdar H, Cohain A, Amadori L, Argmann C, Houten SM, Franzén O, Mocci G, Meelu OA, Ishikawa K, Whatling C, Jain A, Jain RK, Gan LM, Giannarelli C, Roussos P, Hao K, Schunkert H, Michoel T, Ruusalepp A, Schadt EE, Kovacic JC, Lusis AJ, Björkegren JLM. PMID: 36276926; PMCID: PMC9583458.
      View in: PubMed   Mentions: 23  
    41. The Nutritional Supplement L-Alpha Glycerylphosphorylcholine Promotes Atherosclerosis. Int J Mol Sci. 2021 Dec 15; 22(24). Wang Z, Hazen J, Jia X, Org E, Zhao Y, Osborn LJ, Nimer N, Buffa J, Culley MK, Krajcik D, van den Born BH, Zwinderman K, Levison BS, Nieuwdorp M, Lusis AJ, DiDonato JA, Hazen SL. PMID: 34948275; PMCID: PMC8708068.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    42. Roles of Macrophages in Atherogenesis. Front Pharmacol. 2021; 12:785220. Farahi L, Sinha SK, Lusis AJ. PMID: 34899348; PMCID: PMC8660976.
      View in: PubMed   Mentions: 25  
    43. Fecal Microbiome Composition Does Not Predict Diet-Induced TMAO Production in Healthy Adults. J Am Heart Assoc. 2021 11 02; 10(21):e021934. Ferrell M, Bazeley P, Wang Z, Levison BS, Li XS, Jia X, Krauss RM, Knight R, Lusis AJ, Garcia-Garcia JC, Hazen SL, Tang WHW. PMID: 34713713; PMCID: PMC8751816.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    44. Glycogen metabolism links glucose homeostasis to thermogenesis in adipocytes. Nature. 2021 11; 599(7884):296-301. Keinan O, Valentine JM, Xiao H, Mahata SK, Reilly SM, Abu-Odeh M, Deluca JH, Dadpey B, Cho L, Pan A, Yu RT, Dai Y, Liddle C, Downes M, Evans RM, Lusis AJ, Laakso M, Chouchani ET, Rydén M, Saltiel AR. PMID: 34707293; PMCID: PMC9186421.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    45. Sex-specific genetic regulation of adipose mitochondria and metabolic syndrome by Ndufv2. Nat Metab. 2021 11; 3(11):1552-1568. Chella Krishnan K, Vergnes L, Acín-Pérez R, Stiles L, Shum M, Ma L, Mouisel E, Pan C, Moore TM, Péterfy M, Romanoski CE, Reue K, Björkegren JLM, Laakso M, Liesa M, Lusis AJ. PMID: 34697471; PMCID: PMC8909918.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    46. Gene-Environment Interactions for Cardiovascular Disease. Curr Atheroscler Rep. 2021 10 14; 23(12):75. Hartiala JA, Hilser JR, Biswas S, Lusis AJ, Allayee H. PMID: 34648097; PMCID: PMC8903169.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    47. Serum lipids are associated with nonalcoholic fatty liver disease: a pilot case-control study in Mexico. Lipids Health Dis. 2021 Oct 10; 20(1):136. Flores YN, Amoon AT, Su B, Velazquez-Cruz R, Ramírez-Palacios P, Salmerón J, Rivera-Paredez B, Sinsheimer JS, Lusis AJ, Huertas-Vazquez A, Saab S, Glenn BA, May FP, Williams KJ, Bastani R, Bensinger SJ. PMID: 34629052; PMCID: PMC8504048.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
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    198. Genetic Architecture of Atherosclerosis in Mice: A Systems Genetics Analysis of Common Inbred Strains. PLoS Genet. 2015 Dec; 11(12):e1005711. Bennett BJ, Davis RC, Civelek M, Orozco L, Wu J, Qi H, Pan C, Packard RR, Eskin E, Yan M, Kirchgessner T, Wang Z, Li X, Gregory JC, Hazen SL, Gargalovic PS, Lusis AJ. PMID: 26694027; PMCID: PMC4687930.
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    201. Multiple Hepatic Regulatory Variants at the GALNT2 GWAS Locus Associated with High-Density Lipoprotein Cholesterol. Am J Hum Genet. 2015 Dec 03; 97(6):801-15. Roman TS, Marvelle AF, Fogarty MP, Vadlamudi S, Gonzalez AJ, Buchkovich ML, Huyghe JR, Fuchsberger C, Jackson AU, Wu Y, Civelek M, Lusis AJ, Gaulton KJ, Sethupathy P, Kangas AJ, Soininen P, Ala-Korpela M, Kuusisto J, Collins FS, Laakso M, Boehnke M, Mohlke KL. PMID: 26637976; PMCID: PMC4678431.
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    203. Deletion of MLIP (muscle-enriched A-type lamin-interacting protein) leads to cardiac hyperactivation of Akt/mammalian target of rapamycin (mTOR) and impaired cardiac adaptation. J Biol Chem. 2015 Oct 30; 290(44):26699-714. Cattin ME, Wang J, Weldrick JJ, Roeske CL, Mak E, Thorn SL, DaSilva JN, Wang Y, Lusis AJ, Burgon PG. PMID: 26359501; PMCID: PMC4646324.
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    204. The Genetic Architecture of Hearing Impairment in Mice: Evidence for Frequency-Specific Genetic Determinants. G3 (Bethesda). 2015 Sep 04; 5(11):2329-39. Crow AL, Ohmen J, Wang J, Lavinsky J, Hartiala J, Li Q, Li X, Salehide P, Eskin E, Pan C, Lusis AJ, Allayee H, Friedman RA. PMID: 26342000; PMCID: PMC4632053.
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    205. A comprehensive catalogue of the coding and non-coding transcripts of the human inner ear. Hear Res. 2016 Mar; 333:266-274. Schrauwen I, Hasin-Brumshtein Y, Corneveaux JJ, Ohmen J, White C, Allen AN, Lusis AJ, Van Camp G, Huentelman MJ, Friedman RA. PMID: 26341477; PMCID: PMC4775449.
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    207. Genetic and environmental control of host-gut microbiota interactions. Genome Res. 2015 Oct; 25(10):1558-69. Org E, Parks BW, Joo JW, Emert B, Schwartzman W, Kang EY, Mehrabian M, Pan C, Knight R, Gunsalus R, Drake TA, Eskin E, Lusis AJ. PMID: 26260972; PMCID: PMC4579341.
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    208. High-Density Genotypes of Inbred Mouse Strains: Improved Power and Precision of Association Mapping. G3 (Bethesda). 2015 Jul 28; 5(10):2021-6. Rau CD, Parks B, Wang Y, Eskin E, Simecek P, Churchill GA, Lusis AJ. PMID: 26224782; PMCID: PMC4592984.
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    209. Quantitative analysis of 3-dimensional facial soft tissue photographic images: technical methods and clinical application. Prog Orthod. 2015; 16:21. Nanda V, Gutman B, Bar E, Alghamdi S, Tetradis S, Lusis AJ, Eskin E, Moon W. PMID: 26133934; PMCID: PMC4488234.
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    211. The genetic architecture of NAFLD among inbred strains of mice. Elife. 2015 Jun 12; 4:e05607. Hui ST, Parks BW, Org E, Norheim F, Che N, Pan C, Castellani LW, Charugundla S, Dirks DL, Psychogios N, Neuhaus I, Gerszten RE, Kirchgessner T, Gargalovic PS, Lusis AJ. PMID: 26067236; PMCID: PMC4493743.
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    212. Correction: Genome-Wide Association Study Identifies Nox3 as a Critical Gene for Susceptibility to Noise-Induced Hearing Loss. PLoS Genet. 2015 Jun; 11(6):e1005293. Lavinsky J, Crow AL, Pan C, Wang J, Aaron KA, Ho MK, Li Q, Salehide P, Myint A, Monges-Hernadez M, Eskin E, Allayee H, Lusis AJ, Friedman RA. PMID: 26068505; PMCID: PMC4465750.
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    213. The Genetic Landscape of Hematopoietic Stem Cell Frequency in Mice. Stem Cell Reports. 2015 Jul 14; 5(1):125-38. Zhou X, Crow AL, Hartiala J, Spindler TJ, Ghazalpour A, Barsky LW, Bennett BJ, Parks BW, Eskin E, Jain R, Epstein JA, Lusis AJ, Adams GB, Allayee H. PMID: 26050929; PMCID: PMC4618249.
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    214. Unraveling the environmental and genetic interactions in atherosclerosis: Central role of the gut microbiota. Atherosclerosis. 2015 Aug; 241(2):387-99. Org E, Mehrabian M, Lusis AJ. PMID: 26071662; PMCID: PMC4510029.
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    215. Epigenome-wide association of liver methylation patterns and complex metabolic traits in mice. Cell Metab. 2015 Jun 02; 21(6):905-17. Orozco LD, Morselli M, Rubbi L, Guo W, Go J, Shi H, Lopez D, Furlotte NA, Bennett BJ, Farber CR, Ghazalpour A, Zhang MQ, Bahous R, Rozen R, Lusis AJ, Pellegrini M. PMID: 26039453; PMCID: PMC4454894.
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    216. Mechanosensitive PPAP2B Regulates Endothelial Responses to Atherorelevant Hemodynamic Forces. Circ Res. 2015 Jul 31; 117(4):e41-e53. Wu C, Huang RT, Kuo CH, Kumar S, Kim CW, Lin YC, Chen YJ, Birukova A, Birukov KG, Dulin NO, Civelek M, Lusis AJ, Loyer X, Tedgui A, Dai G, Jo H, Fang Y. PMID: 26034042; PMCID: PMC4522239.
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    217. Genetics of common forms of heart failure: challenges and potential solutions. Curr Opin Cardiol. 2015 May; 30(3):222-7. Rau CD, Lusis AJ, Wang Y. PMID: 25768955; PMCID: PMC4406340.
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    218. Scavenger receptor class A member 5 (SCARA5) and suprabasin (SBSN) are hub genes of coexpression network modules associated with peripheral vein graft patency. J Vasc Surg. 2016 07; 64(1):202-209.e6. Kenagy RD, Civelek M, Kikuchi S, Chen L, Grieff A, Sobel M, Lusis AJ, Clowes AW. PMID: 25935274; PMCID: PMC4627903.
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    221. ABCC6 deficiency is associated with activation of BMP signaling in liver and kidney. FEBS Open Bio. 2015; 5:257-63. Blazquez-Medela AM, Guihard PJ, Yao J, Jumabay M, Lusis AJ, Boström KI, Yao Y. PMID: 25893161; PMCID: PMC4398664.
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    222. Genetic architecture of insulin resistance in the mouse. Cell Metab. 2015 Feb 03; 21(2):334-347. Parks BW, Sallam T, Mehrabian M, Psychogios N, Hui ST, Norheim F, Castellani LW, Rau CD, Pan C, Phun J, Zhou Z, Yang WP, Neuhaus I, Gargalovic PS, Kirchgessner TG, Graham M, Lee R, Tontonoz P, Gerszten RE, Hevener AL, Lusis AJ. PMID: 25651185; PMCID: PMC4349439.
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    224. The TMAO-Generating Enzyme Flavin Monooxygenase 3 Is a Central Regulator of Cholesterol Balance. Cell Rep. 2015 Jan 20; 10(3):326-338. Warrier M, Shih DM, Burrows AC, Ferguson D, Gromovsky AD, Brown AL, Marshall S, McDaniel A, Schugar RC, Wang Z, Sacks J, Rong X, Vallim TA, Chou J, Ivanova PT, Myers DS, Brown HA, Lee RG, Crooke RM, Graham MJ, Liu X, Parini P, Tontonoz P, Lusis AJ, Hazen SL, Temel RE, Brown JM. PMID: 25600868; PMCID: PMC4501903.
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    225. Transmission of atherosclerosis susceptibility with gut microbial transplantation. J Biol Chem. 2015 Feb 27; 290(9):5647-60. Gregory JC, Buffa JA, Org E, Wang Z, Levison BS, Zhu W, Wagner MA, Bennett BJ, Li L, DiDonato JA, Lusis AJ, Hazen SL. PMID: 25550161; PMCID: PMC4342477.
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    227. PON3 knockout mice are susceptible to obesity, gallstone formation, and atherosclerosis. FASEB J. 2015 Apr; 29(4):1185-97. Shih DM, Yu JM, Vergnes L, Dali-Youcef N, Champion MD, Devarajan A, Zhang P, Castellani LW, Brindley DN, Jamey C, Auwerx J, Reddy ST, Ford DA, Reue K, Lusis AJ. PMID: 25477283; PMCID: PMC4396607.
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    228. Estrogen receptor (ER)α-regulated lipocalin 2 expression in adipose tissue links obesity with breast cancer progression. J Biol Chem. 2015 Feb 27; 290(9):5566-81. Drew BG, Hamidi H, Zhou Z, Villanueva CJ, Krum SA, Calkin AC, Parks BW, Ribas V, Kalajian NY, Phun J, Daraei P, Christofk HR, Hewitt SC, Korach KS, Tontonoz P, Lusis AJ, Slamon DJ, Hurvitz SA, Hevener AL. PMID: 25468909; PMCID: PMC4342471.
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    229. Macrophage polarization phenotype regulates adiponectin receptor expression and adiponectin anti-inflammatory response. FASEB J. 2015 Feb; 29(2):636-49. van Stijn CM, Kim J, Lusis AJ, Barish GD, Tangirala RK. PMID: 25392268; PMCID: PMC4314235.
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    232. γ-Butyrobetaine is a proatherogenic intermediate in gut microbial metabolism of L-carnitine to TMAO. Cell Metab. 2014 Nov 04; 20(5):799-812. Koeth RA, Levison BS, Culley MK, Buffa JA, Wang Z, Gregory JC, Org E, Wu Y, Li L, Smith JD, Tang WHW, DiDonato JA, Lusis AJ, Hazen SL. PMID: 25440057; PMCID: PMC4255476.
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    233. Reducing macrophage proteoglycan sulfation increases atherosclerosis and obesity through enhanced type I interferon signaling. Cell Metab. 2014 Nov 04; 20(5):813-826. Gordts PLSM, Foley EM, Lawrence R, Sinha R, Lameda-Diaz C, Deng L, Nock R, Glass CK, Erbilgin A, Lusis AJ, Witztum JL, Esko JD. PMID: 25440058; PMCID: PMC4254584.
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    235. Regulation of NF-κB signaling by oxidized glycerophospholipid and IL-1β induced miRs-21-3p and -27a-5p in human aortic endothelial cells. J Lipid Res. 2015 Jan; 56(1):38-50. Romay MC, Che N, Becker SN, Pouldar D, Hagopian R, Xiao X, Lusis AJ, Berliner JA, Civelek M. PMID: 25327529; PMCID: PMC4274069.
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    238. Individual diet has sex-dependent effects on vertebrate gut microbiota. Nat Commun. 2014 Jul 29; 5:4500. Bolnick DI, Snowberg LK, Hirsch PE, Lauber CL, Org E, Parks B, Lusis AJ, Knight R, Caporaso JG, Svanbäck R. PMID: 25072318; PMCID: PMC4279269.
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    248. Deficiency of CCAAT/enhancer binding protein-epsilon reduces atherosclerotic lesions in LDLR-/- mice. PLoS One. 2014; 9(1):e85341. Okamoto R, Gery S, Gombart AF, Wang X, Castellani LW, Akagi T, Chen S, Arditi M, Ho Q, Lusis AJ, Li Q, Koeffler HP. PMID: 24489659; PMCID: PMC3904867.
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    250. Macrophage accumulation in atherosclerosis. N Engl J Med. 2013 Dec 12; 369(24):2352-3. Parks BW, Lusis AJ. PMID: 24328470; PMCID: PMC3934498.
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    450. Identification of macrophage liver X receptors as inhibitors of atherosclerosis. Proc Natl Acad Sci U S A. 2002 Sep 03; 99(18):11896-901. Tangirala RK, Bischoff ED, Joseph SB, Wagner BL, Walczak R, Laffitte BA, Daige CL, Thomas D, Heyman RA, Mangelsdorf DJ, Wang X, Lusis AJ, Tontonoz P, Schulman IG. PMID: 12193651; PMCID: PMC129365.
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    451. Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice. Circ Res. 2002 Jul 26; 91(2):120-6. Mehrabian M, Allayee H, Wong J, Shi W, Wang XP, Shaposhnik Z, Funk CD, Lusis AJ, Shih W. PMID: 12142344.
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    452. Decreased atherosclerotic lesion formation in human serum paraoxonase transgenic mice. Circulation. 2002 Jul 23; 106(4):484-90. Tward A, Xia YR, Wang XP, Shi YS, Park C, Castellani LW, Lusis AJ, Shih DM. PMID: 12135950.
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    453. Myeloperoxidase, a leukocyte-derived vascular NO oxidase. Science. 2002 Jun 28; 296(5577):2391-4. Eiserich JP, Baldus S, Brennan ML, Ma W, Zhang C, Tousson A, Castro L, Lusis AJ, Nauseef WM, White CR, Freeman BA. PMID: 12089442.
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    455. Synthetic LXR ligand inhibits the development of atherosclerosis in mice. Proc Natl Acad Sci U S A. 2002 May 28; 99(11):7604-9. Joseph SB, McKilligin E, Pei L, Watson MA, Collins AR, Laffitte BA, Chen M, Noh G, Goodman J, Hagger GN, Tran J, Tippin TK, Wang X, Lusis AJ, Hsueh WA, Law RE, Collins JL, Willson TM, Tontonoz P. PMID: 12032330; PMCID: PMC124297.
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    456. Locus for elevated apolipoprotein B levels on chromosome 1p31 in families with familial combined hyperlipidemia. Circ Res. 2002 May 03; 90(8):926-31. Allayee H, Krass KL, Pajukanta P, Cantor RM, van der Kallen CJ, Mar R, Rotter JI, de Bruin TW, Peltonen L, Lusis AJ. PMID: 11988495.
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    457. Paradoxical reduction of fatty streak formation in mice lacking endothelial nitric oxide synthase. Circulation. 2002 Apr 30; 105(17):2078-82. Shi W, Wang X, Shih DM, Laubach VE, Navab M, Lusis AJ. PMID: 11980688.
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    458. Neutrophils and NADPH oxidase mediate intrapancreatic trypsin activation in murine experimental acute pancreatitis. Gastroenterology. 2002 Apr; 122(4):974-84. Gukovskaya AS, Vaquero E, Zaninovic V, Gorelick FS, Lusis AJ, Brennan ML, Holland S, Pandol SJ. PMID: 11910350.
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    459. Understanding atherosclerosis through mouse genetics. Curr Opin Lipidol. 2002 Apr; 13(2):181-9. Sheth SS, Deluna A, Allayee H, Lusis AJ. PMID: 11891421.
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    460. A tale of two controversies: defining both the role of peroxidases in nitrotyrosine formation in vivo using eosinophil peroxidase and myeloperoxidase-deficient mice, and the nature of peroxidase-generated reactive nitrogen species. J Biol Chem. 2002 May 17; 277(20):17415-27. Brennan ML, Wu W, Fu X, Shen Z, Song W, Frost H, Vadseth C, Narine L, Lenkiewicz E, Borchers MT, Lusis AJ, Lee JJ, Lee NA, Abu-Soud HM, Ischiropoulos H, Hazen SL. PMID: 11877405.
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    461. Transgenic expression of cholesterol-7-alpha-hydroxylase prevents atherosclerosis in C57BL/6J mice. Arterioscler Thromb Vasc Biol. 2002 Jan; 22(1):121-6. Miyake JH, Duong-Polk XT, Taylor JM, Du EZ, Castellani LW, Lusis AJ, Davis RA. PMID: 11788471.
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    462. Positional cloning of the combined hyperlipidemia gene Hyplip1. Nat Genet. 2002 Jan; 30(1):110-6. Bodnar JS, Chatterjee A, Castellani LW, Ross DA, Ohmen J, Cavalcoli J, Wu C, Dains KM, Catanese J, Chu M, Sheth SS, Charugundla K, Demant P, West DB, de Jong P, Lusis AJ. PMID: 11753387; PMCID: PMC2846781.
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    463. Atherosclerosis. Nature. 2000 Sep 14; 407(6801):233-41. Lusis AJ. PMID: 11001066; PMCID: PMC2826222.
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